北京市2007年健康人群白喉抗体水平监测分析  

Analysis of Diphtheria Antibody Levels in Healthy Population in Beijing Municipal,2007

作　　者：李晓梅[1] 刘东磊[1] 杨洁[1] 

机构地区：[1]北京市疾病预防控制中心,北京100013

出　　处：《中国疫苗和免疫》2010年第3期222-224,共3页Chinese Journal of Vaccines and Immunization

摘　　要：目的了解北京市2007年健康人群白喉抗体水平。方法采用分层多级抽样的方法,调查北京市9个区(县)<1、1～4、5～9、10～14、15～19、20～24、25～29、30～34、35～39、≥40岁健康人群共2003人,用酶联免疫吸附试验测定白喉抗体。结果白喉抗体阳性率为60.26%,平均浓度为0.62IU/m(l国际单位/毫升)。抗体水平随年龄增长和免疫后时间延长而逐渐下降,25～29岁人群抗体水平最低。结论预测北京市近期不会出现白喉流行。推荐成人每10年进行一次白类或含白类成份疫苗的加强免疫。Objective To investigate the diphtheria antibody level in healthy population in Beijing.Methods10 age groups（1,1 to 4,5 to 9,10 to 14,15 to 19,20 to 24,25 to 29,30 to 34,35 to 39,and ≥40） were sampled by the Multi-stage stratified sampling method in 9 districts in Beijing,and 2 003 sera from healthy population were collected.The diphtheria antibody was determined with ELISA method.ResultsThe diphtheria antibody-positive rate was 60.26%,and the antibody concentration was 0.62IU/ml.A trend of decreasing in the antibody concentration was observed with increasing age and years after immunization.Antibody levels were the lowest in healthy people between 25～40 years old.ConclusionIt was predicted that a large scale of diphtheria outbreak would not occur recently in Beijing.It is recommended that for all adults diphtheria toxoids booster immunization should be conducted every 10 years for all adults.

关 键 词：白喉 抗体 监测 

分 类 号：R725.171[医药卫生—儿科]