依法克生及咪唑克生对胍丁胺抗抑郁活性的阻断作用  

The relationship between imidazoline receptors and the antidepressant-like effect of agmatine

作　　者：李亮[1,2] 苏瑞斌[1] 李锦[1] 

机构地区：[1]军事医学科学院毒物药物研究所,北京100850 [2]海军总医院麻醉科,北京100037

出　　处：《军事医学科学院院刊》2010年第3期239-242,共4页Bulletin of the Academy of Military Medical Sciences

基　　金：国家重点基础研究发展计划(973计划)(2007CB512307);国家高技术研究发展计划(863计划)(2008AA02Z402);国家"重大新药创制"科技重大专项(2009ZX09102-006);北京市自然科学基金重点项目(7081003)

摘　　要：目的明确胍丁胺抗抑郁作用与咪唑啉受体的关系。方法与结果连续给予CD-1小鼠胍丁胺(10mg/kg,qd,ig)3d,最后一次给药后1h进行强迫游泳或悬尾实验,与盐水对照组相比,胍丁胺可以显著缩短小鼠强迫游泳及悬尾不动时间(P<0.05);连续给予依法克生(0.1mg/kg,qd,ip)或咪唑克生(1mg/kg,qd,ip)3d,最后一次给药后30min进行实验,对小鼠强迫游泳及悬尾不动时间均无显著影响(P>0.05);但伴随胍丁胺连续给予(15min前),依法克生(0.1mg/kg)及咪唑克生(1mg/kg)均能逆转胍丁胺缩短小鼠强迫游泳及悬尾不动时间的作用(P<0.05)。结论胍丁胺对小鼠具有抗抑郁样作用,且与激活咪唑啉受体相关。Objective To investigate the relationship between imidazoline receptors（I-R）and the antidepressant-like effect of agmatine.Methods and Results The CD-1 mice were treated with agmatine（10 mg/kg,ig）once daily for 3 days.The last dose was given 1 h before the tests.Significant reduction in the duration of immobility was observed in the forced swimming test（FST）and the tail suspension test（TST）.After treatment with efaroxan（0.1 mg/kg,ip）or idazoxan（1 mg/kg,ip）once daily for 3 days,the last dose was given 30 min before the tests.There were no obvious changes in the immobility time.Concomitant pretreatment of efaroxan（0.1 mg/kg,ip）or idazoxan（1 mg/kg,ip）significantly suppressed the decrease in immobility time caused by agmatine in the FST and the TST.Conclusion Agmatine has antidepressant-like effect related to stimulation of I-R.

关 键 词：咪唑啉受体 胍丁胺 抑郁 

分 类 号：R964[医药卫生—药理学] R971.4[医药卫生—药学]