CpG寡脱氧核苷酸为佐剂的丙型肝炎生物治疗研究进展  

Advances in research on CpG oligodeoxynucleotides for treatment of hepatitis C

作　　者：湛娜[1] 张贺秋[2] 郭宁[2] 凌世淦[2] 

机构地区：[1]解放军307医院,北京100071 [2]军事医学科学院基础医学研究所,北京100850

出　　处：《军事医学科学院院刊》2010年第3期297-300,共4页Bulletin of the Academy of Military Medical Sciences

基　　金：国家"十一五"科技重大专项(2008ZX10002-013);国家"重大新药创制"科技重大专项(2009ZX09103-621)

摘　　要：丙型肝炎严重威胁人类健康,并在全球范围内流行,目前尚无有效办法预防和治疗丙型肝炎病毒感染,胞苷酸鸟苷(CpG)寡脱氧核苷酸(CpGODN)作为一类较强的免疫调节佐剂,能够广泛诱导交叉中和性抗体和细胞免疫反应,对丙型肝炎病毒感染具有治疗作用。本文对以CpGODN为佐剂的丙型肝炎生物治疗研究进展予以综述。Hepatitis C virus（HCV）infection is an important infectious disease threatening human health worldwide.No vaccine is currently available for prevention and cure of HCV infection.Cytidine phosphate guanosine oligodeoxynucleotides（CpG ODN）,as the potent regulators of immunity,can induce broad cross neutralizing antibodies,strengthen the cellular immune responses and may serve as a candidate for treatment of HCV infection.Research progress in CpG ODN for treating hepatitis C virus infection is reviewed.

关 键 词：丙型肝炎病毒 CPG寡脱氧核苷酸 佐剂 免疫 

分 类 号：R392[医药卫生—免疫学] R512.63[医药卫生—基础医学]