转录因子Sp1影响抵抗素基因表达的研究进展  

Transcription factor Sp1 and resistin

作　　者：时晓明[1,2] 郭秀丽[1] 高伟[3] 纪国力 

机构地区：[1]山东大学药学院新药药理研究室,济南250012 [2]泰山医学院机能实验室,泰安271000 [3]山东泰安市药品检验所,泰安271000 [4]解放军第八十八医院呼吸科,泰安271000

出　　处：《药物分析杂志》2010年第7期1329-1331,共3页Chinese Journal of Pharmaceutical Analysis

摘　　要：抵抗素起初认为与胰岛素抵抗有关,近来的研究结果表明其作用广泛,与炎症、代谢、免疫和肿瘤等关系密切。近年来的研究表明转录因子Sp1对抵抗素基因的表达有着重要影响,这对于阐明抵抗素作用的详细分子机制,为临床防治抵抗素相关的疾病提供了一个新的分子靶点。Resisting was originally identified as a hormone that induced insulin resistance in rodents with increasing evidences indicate its important regulatory roles in various biological process,including inflammatory disease,metabolism,tumor and immunity.Recent research results showed that transcription factor Sp1 plays an important role upon expression of resistin gene,and it was beneficial to elucidate the precise mechanism of resistant actions,and provide a new molecular target for the prevention and therapy of diseases involved with resistin.

关 键 词：抵抗素 转录因子SP1 

分 类 号：R917[医药卫生—药物分析学]