细菌纤维素的生物相容性研究  

Biocompatibility research of the bacterial cellulose

作　　者：郑琪[1] 奚廷斐[1,2,3] 陈艳梅[2] 王召旭[3] 万怡灶[4] 高川[4] 

机构地区：[1]温州医学院信息与工程学院,温州325035 [2]北京大学前沿学科交叉研究院,北京100871 [3]中国药品生物制品检定所,北京100050 [4]天津大学材料科学与工程学院,天津300072

出　　处：《药物分析杂志》2010年第7期1389-1392,共4页Chinese Journal of Pharmaceutical Analysis

摘　　要：细菌纤维素是一种天然的生物高分子材料。作为组织工程支架材料,细菌纤维素在人工软骨、人工血管、人工皮肤等领域的应用逐渐受到研究者的重视。本文分别进行亚急性毒性实验,细胞毒性实验及电镜实验评价细菌纤维素的生物相容性。结果表明,细菌纤维素具有良好的生物相容性,是一种很有前景的医用生物材料。Bacterial cellulose（BC）is a natural bio-polymerized material.As tissue engineering scaffolds,BC gradually were taken seriously by researchers on artificial cartilage,artificial blood vessel and artificial skin,etc.The subacute systemic toxicity and cytotoxicity of BC were studied for biocompatibility and biological safety evaluation.Transmitting electron microscopy and light microscopy were used in this study.The results indicated that BC have excellent biocompatibility,and will be a prospected safe biomedical material.

关 键 词：细菌纤维素 毒性实验 电镜 生物相容性 

分 类 号：R917[医药卫生—药物分析学]