辛伐他汀对心肌梗死后血管新生及血管生成素-1的影响  

Effects of simvastatin on angiogenesis and the expression of Ang-1 in rats with acute myocardial infarction

作　　者：王惠[1] 覃数[1] 何泉[1] 杨义[1] 刘俊[1] 彭艳[1] 

机构地区：[1]重庆医科大学附属第一医院心内科,重庆400016

出　　处：《临床心血管病杂志》2010年第6期453-456,共4页Journal of Clinical Cardiology

基　　金：重庆市自然科学基金资助项目[No:渝发科技字(2004)54号文]

摘　　要：目的:观察辛伐他汀对大鼠急性心肌梗死(AMI)后血管新生的影响,以及血管生成素-1(Ang-1)在这一过程中的表达变化。方法:SD大鼠60只,随机分为假手术组、对照组、小剂量辛伐他汀(1mg.kg-1.d-1)组、中剂量辛伐他汀(10mg.kg-1.d-1)组、大剂量辛伐他汀(40mg.kg-1.d-1)组。结扎大鼠冠状动脉左前降支建立AMI动物模型。术后次日起分别灌胃给予相应剂量辛伐他汀4周。检测缺血区心肌新生血管密度、左室重量指数(LVMI)、及Ang-1蛋白及mRNA表达。结果:小剂量及中剂量辛伐他汀组缺血区心肌新生血管密度较对照组显著增加(P<0.05);各剂量辛伐他汀组Ang-1蛋白及mRNA表达较对照组均显著增强(P<0.05);小、中剂量辛伐他汀组LVMI较对照组显著减小(P<0.05),大剂量组LVMI则进一步减小(P<0.01)。结论:小、中剂量辛伐他汀可促进AMI后心肌血管新生;辛伐他汀这一作用可能与其上调Ang-1的表达有关。Objective：To investigate the effects of simvastatin on myocardial angiogenesis and the expression of angiopoietin-1 （Ang-1） after experimental acute myocardial infarction （AMI） in rats.Method：The 60 healthy adult SD rats were randomly divided into the sham operated group,the control group,low dose of simvastatin （1 mg·kg-1·d-1） group,medium dose of simvastatin （10 mg·kg-1·d-1） group,and high dose of simvastatin （40 mg·kg-1·d-1） group.Left anterior descending coronary underwent permanent occlusion to establish the MI model.Rats were administered simvastatin respectively via oral gavage for 4 consecutive weeks starting at the next day after operation.Density of new microvessels in the ischemic area,LVMI,protein and mRNA expression of Ang-1 were detected 4 weeks after operation.Result：Compared with the control group,the density of new microvessels in low and medium dose of simvastatin group increased significantly （P0.05）;LVMI in low and medium dose of simvastatin group decreased significantly compared with that in control group （P0.05）,and further decreased in high dose of simvastatin group;the protein and mRNA expression of Ang-1 in all simvastatin group increased significantly compared with those in control group （P0.05）.Conclusion：Low and medium dose of simvastatin can stimulate myocardial angiogenesis after MI;the pro-angiogenic effect of simvastatin may be associated with upregulated expression of Ang-1.

关 键 词：急性心肌梗死 辛伐他汀 血管新生 血管生成素-1 

分 类 号：R542.2[医药卫生—心血管疾病]