Box-Behnken设计-效应面法优化淫羊藿总黄酮微孔渗透泵片处方  

Optimization of total epimediumon flavone microporosity osmotic pump tablet formulation by box-behnken design and response surface methodology

作　　者：魏萍[1] 尹蓉莉[1] 李东芬[1] 吴圣琴[1] 陈金玉[1] 

机构地区：[1]成都中医药大学,四川成都611137

出　　处：《中成药》2010年第7期1124-1128,共5页Chinese Traditional Patent Medicine

摘　　要：目的:应用Box-Behnken设计-效应面法优化淫羊藿总黄酮微孔渗透泵片处方。方法:以渗透压活性物质用量(乳糖)、增塑剂用量(邻苯二甲酸二丁酯)、包衣增重量为影响片剂释放的主要因素,以12h的药物累积释药量和释放曲线拟合度为效应值,应用Design Expert进行处方优化,并对优化处方进行验证。结果:成功找到了最优释药区域;优化后处方呈零级释放特性。结论:淫羊藿总黄酮微孔渗透泵片的最佳赋形剂配方是0.18g乳糖,邻苯二甲酸二丁酯与醋酸纤维素之比是0.26,片剂增量为7.7%。AIM：To optimize total flavone of herba epimediumon microporosity osmotic pump tablets by boxbehnken design-response surface methodology. METHODS：Osmotic agent （lactose）,dosage of plastificator （dibutyl phthalate）,and coating weight gain were selected as key factors of influencing total flavone delivery. Total flavones cumulatiive yield in 12 h and fitting approximation was regarded as the response. Design Expert method useful for the modeling and analysis was to optimize the response. RESULTS：Response surface surface obtained repre-sented maximum one which conformed to the zero-order delivery rate equation. CONCLUSION：Optimal excipient formulation of total epimedium flavone microporosity osmotic pump tablet consists of 0. 18 g of lactose,0. 26 ratio of dibutyl phthalate to acetyl celulose and 7. 7% of coating weight gain.

关 键 词：淫羊藿总黄酮 微孔渗透泵片 效应面 

分 类 号：R944[医药卫生—药剂学]