南蛇藤根皮的化学成分研究  

Chemical constituents of the bark of Celastrus orbiculatus

作　　者：刘惠玲[1] 冯玉静[2] 陈定双[1] 王定勇[2] 

机构地区：[1]广东省中医院药学部,广东广州510120 [2]广东药学院药科学院,广东广州510006

出　　处：《中成药》2010年第7期1169-1172,共4页Chinese Traditional Patent Medicine

摘　　要：目的:对卫矛科南蛇藤属植物南蛇藤的根皮进行化学成分研究。方法:用乙醇冷浸提取南蛇藤根,得到的萃取物减压回收,得到的干浸膏分别用石油醚和乙酸乙酯萃取。两萃取物再采用色谱法进行分离,波谱法鉴定结构。结果:从该植物中共分离鉴定出7个化合物,从石油醚萃取物中得到5个化合物分别是12-羟基-8,11,13-松香烷三烯-7-酮(1)、扁蒴藤素(2)、β-谷甾醇(3)、雷公藤红素(4)、大子五层龙酸(5);从乙酸乙酯萃取物得到2个化合物,分别为苯甲酸(6)、胡萝卜苷(7)。结论:化合物1、5均为首次从该植物中分离得到。AIM：To study the chemical constitutes of Celastrus orbiculatus Thunb. METHODS：Root of celastmus orbiculatus was macerated with cool ethanol to obtain the extract under the vaccum drying processing,extract obtained was extracted respectively by petroleum ester and ethyl acetate. Final extracts were purified by Silicagel column and analyzed by UV,IR,Ms and NMR to identify the chemical structural formula. RESULTS：Seven compounds were isolated from Celastrus orbiculatus Thunb,from which five constituents came from petroleum ester extract,and identified as sugiol （1）,pristimerin （2）,β-sitosterol （3）,celastrol （4）,from which two constituents came from ethyl acetate extract,salapermic acid（5）,benzoic acid （6） and daucosterol （7）,respectively. CONCLUSION：Compounds 1,5 were obtained from the plant for the first time.

关 键 词：南蛇藤 化学成分 扁蒴藤素 

分 类 号：R284.1[医药卫生—中药学]