Kanglemycin C vs ciclosporin on immunosuppression in mice  

作　　者：李建明[1] 林志彬[1] 

机构地区：[1]北京医科大学药理系

出　　处：《中国药理学报》1999年第1期65-68,共4页Acta Pharmacologica Sinica

摘　　要：目的：与环孢素（Ｃｉｃ）比较，研究康乐霉素Ｃ（Ｋａｎ）对小鼠免疫系统的影响．方法：皮肤迟发性超敏反应（ＤＨ）和环磷酰胺（Ｃｙｃ）增强型ＤＨ；同种异型皮肤和心脏移植；脾细胞溶血素测定；腹腔巨噬细胞吞噬中性红．结果：Ｋａｎ（１２５，２５，５０ｍｇ·ｋｇ－１·ｄ－１，ｉｇ，８ｄ）与Ｃｉｃ相似，抑制小鼠皮肤ＤＨ和Ｃｙｃ增强型ＤＨ（Ｐ＜００１）；延长小鼠同种异型皮肤和心脏移植物存活时间（Ｐ＜００１）；对溶血素产生也有抑制作用（Ｐ＜００１）；Ｋａｎ５０ｍｇ·ｋｇ－１·ｄ－１，ｉｇ，５ｄ与Ｃｙｃ相似，对小鼠腹腔巨噬细胞吞噬中性红无明显作用（Ｐ＞００５）．结论：Ｋａｎ显著抑制小鼠细胞免疫和体液免疫，但不影响巨噬细胞的吞噬．AIM: To study inhibitory effects of kanglemycin C (Kan) on the mouse immune system, and compare with the effects of ciclosporin (Cic). METHODS: Delayed hypersensitivity (DH) and cyclophosphamide potentiated DH induced by dinitrofluorobenzene (DNFB); heart allograft and skin allograft; hemolysin; the phagocytosis of the peritoneal macrophage. RESULTS: Kan (12 5, 25, 50 mg·kg -1 ·d -1 , ig, 8 d) mark￣ed￣ly inhibited DH and cyclo￣phosphamide potentiated DH induced by DNFB ( P <0 01), prolonged survival times of heart and skin allografts ( P <0 01), and decreased the content of hemolysin ( P <0 01), but had no significant effect on the neutral red phagocytosis of the peritoneal macro￣phage ( P >0 05). CON￣CLU￣SION: Kan had marked suppressive effects on cell mediated and humoral mediated immune responses, but no effect on phagocytosis of macrophage.

关 键 词：康乐霉素C 环孢素 同种移植 免疫抑制 

分 类 号：R979.5[医药卫生—药品]