血管紧张素转换酶2在糖尿病大鼠早期心肌组织中的表达  

Explore of angiotensin-converting enzyme 2 expression in diabetic rat myocardium

作　　者：胡园园[1] 沈洁[1,2] 朱艳[1] 刘帅[3] 唐杰龙[1] 

机构地区：[1]南方医科大学南方医院内分泌代谢科,510515 [2]南方医科大学 [3]广东省佛山市南海区人民医院,528200

出　　处：《实用医学杂志》2010年第13期2296-2298,共3页The Journal of Practical Medicine

摘　　要：目的：观察糖尿病早期大鼠心肌组织中血管紧张素转换酶2（ACE2）mRNA的表达。方法：将21只8周龄雄性Wistar大鼠，随机分为正常对照组（n=7）和糖尿病组（n=14），一次性腹腔注射链脲佐菌素55mg／kg．72h后血糖大于16．7mmol／L纳入糖尿病组，饲养12周。采用实时定量PCR（RT—PcR）检测正常及糖尿病大鼠心肌组织ACE2的基因表达。结果：与正常对照组相比，糖尿病组大鼠心肌组织ACE2mRNA表达显著增加（P〈0．05）。结论：在糖尿病早期，大鼠心肌组织ACE2mRNA的表达增加。Objective To observe the angiotensin-converting enzyme 2 （ACE2） mRNA expression in diabetic rat myocardium in early stage of diabetes. Methods Twenty-one 8-week male Wistar rats were randomly divided into control group（n = 7） and diabetes group（n = 14）. Diabetes was induced by a single intraperitoneal injection of STZ（55 mg/kg）, after 72 h blood glucose 〉 16.7 mmol/L as diabetes. Myocardial ACE2 mRNA expression was respectively determined by real-time PCR（RT-PCR） in control group and diabetes group. Results Compared with the control group, myocardial ACE2 mRNA expression（P 〈 0.05） was significantly increased in diabetes group. Conclusion In early stage of diabetes, diabetic rat myocardial ACE2 mRNA expression was increased.

关 键 词：糖尿病 心肌组织 血管紧张素转换酶2 

分 类 号：R587.1[医药卫生—内分泌]