碳酸钙泡腾颗粒吸湿性及稳定性研究  

STUDY ON HYDROSCOPICITY AND STABILITY OF THE CALCIUM CARBONATE EFFERVESCENT GRANULES

作　　者：程小宁[1] 周天杰[1] 赵劲松 熊宏智 王晓敏[1] 

机构地区：[1]华西医科大学附属第四医院

出　　处：《华西药学杂志》1999年第1期29-31,共3页West China Journal of Pharmaceutical Sciences

摘　　要：对自制碳酸钙泡腾颗粒进行了吸湿性、光照、高湿、高温试验，加速试验及室温留样观察。结果表明，ＣＲＨ为６０％。在裸露条件下对温敏感，对热稳定，在市售包装下对湿、热都比较稳定。The hydroscopicity and the stability studies of calcium carbonate effervescent granules were carried out. The quality control criteria in stability study were the description, the pH of the solution, the effervescent rate and quantity, and the content of soluble calcium. The results showed that the CRH of calcium carbonate effervescent granules was 60%, high temperature had little effect on the stability of calcium carbonate effervescent ganules, and high humidity and the light, can make this prepartion unstable. Three months accelerate test and 36 months room temperature test indicate good stability of calcium carbonate effervescent granules.

关 键 词：碳酸钙泡腾颗粒 稳定性 吸湿性 

分 类 号：R977.9[医药卫生—药品] R927.11[医药卫生—药学]