血小板活化因子在烧伤大鼠早期肠源性内毒素血症发病中的作用  

Pathogenetic effect of platelet activating factor on enterogenic endotoxemia after burn

作　　者：余佩武[1] 肖光夏[1] 府伟灵[1] 袁建成[1] 秦孝健[1] 周立新[1] 

机构地区：[1]第三军医大学西南医院普通外科

出　　处：《中华医学杂志》1999年第2期136-138,共3页National Medical Journal of China

基　　金：国家自然科学基金

摘　　要：目的探讨血小板活化因子（ＰＡＦ）对烧伤后肠源性内毒素血症的影响。方法选用健康Ｗｉｓｔａｒ大鼠９０只制成３０％体表Ⅲ度烫伤模型，随机分为３组，正常对照组，单纯烫伤组，ＰＡＦ拮抗剂治疗组观察ＰＡＦ水平变化与肠源性内毒素血症的关系。结果大鼠烫伤后４８小时内肠粘膜通透性和血浆内毒素水平均显著升高，伤后１２小时为最高，分别为（０５８±０１８）ｍｌ·ｍｉｎ－１·１００ｇ－１、（１２９±２２）ｎｇ／Ｌ，与肠组织和血ＰＡＦ水平升高呈显著相关；ＰＡＦ拮抗剂治疗能显著降低肠粘膜通透性和血浆内毒素水平。健康大鼠静脉注射外源性ＰＡＦ后，肠粘膜通透性和血浆内毒素水平也显著升高，且与ＰＡＦ剂量呈显著依赖关系。结论大鼠烫伤后血浆及肠组织中ＰＡＦ水平升高是导致早期肠源性内毒素血症的一个重要因素。Objective To investigate the effects of platelet activating factor (PAF) on the occurence of enterogenic endotoxemia after burn. Methods The relationship between changes of PAF and enterogenic endotoxima was observed on a model of rats with 30% TBSA Ⅲ° burn. Results The intestinal permeability and plasma endotoxin were significantly elevated and were positively correlated with the increase of PAF in the intestinal tissue and blood. PAF antagonist treatment significantly decreased the intestinal permeability and the levels of plasma endotoxin. After intravenous injection of enogenous PAF to healthy rats, the intestinal permeability and plasma endotoxin were also markedly increased, which was significantly depended on the dose of PAF. Conclusion PAF is one of the important factors for the occurence of postburn enterogenic endotoximia.

关 键 词：血小板活化因子 烧伤 通透性 内毒素血症 

分 类 号：R644[医药卫生—外科学]