紫杉醇联合奥沙利铂和5-氟尿嘧啶治疗进展期胃癌的前瞻性研究  

Prospective Study on Paclitaxel Combined with Oxaliplatin and 5-fluorouracil in the Treatment of Advanced Gastric Cancer

作　　者：汪华蓉[1] 孙支芳[1] 张伏军[1] 易发红[1] 

机构地区：[1]重庆三峡中心医院药剂科,重庆市404000

出　　处：《中国药房》2010年第28期2637-2639,共3页China Pharmacy

摘　　要：目的:研究紫杉醇联合奥沙利铂和5-氟尿嘧啶治疗进展期胃癌的疗效及不良反应。方法:31例进展期胃癌患者均给予紫杉醇175mg·m-2,静脉滴注3h,第1天;草酸铂85mg·m-2,静脉滴注,第1天;5-氟尿嘧啶500mg·m-2用电脑控制微量输液泵24h维持泵入,第1～5天。每3周重复。主要观察总有效率,其次观察生存期和不良反应。结果:31例患者总有效率为38.7%(12/31),其中完全缓解(9.7%,3/31),部分缓解(29.0%,9/31),稳定(41.9%,13/31),进展(19.4%,6/31)。中位疾病进展时间(TTP)5.9个月,中位生存期(MST)10.7个月。其中初治患者总有效率70%;复治患者有效率23.8%。主要不良反应为神经毒性(89.1%)、白细胞减少(82.6%)、恶心/呕吐(72.8%)、脱发(66.3%)。全组未见化疗相关性死亡。结论:紫杉醇联合奥沙利铂和5-氟尿嘧啶治疗进展期胃癌有较好的疗效,患者耐受性良好。OBJECTIVE：To study the clinical efficacy and adverse drug reactions （ADR） of paclitaxel combined with oxaliplatin and 5-fluorouracil （5-Fu） in the treatment of advanced gastric cancer.METHODS：31 patients with advanced gastric cancer were treated with paclitaxel 175 mg·m-2 （i.v.） for 3 hours followed by oxaliplatin 85 mg·m-2 on the first day and 24 hour infusion of 5-Fu （500 mg·m-2,first to fifth day） every 3 weeks.Total effective rate,survival duration and ADR were observed.RESULTS：The total effective rate was 38.7% （12/31）,including complete remission of 9.7% （3/31）,partial remission of 29.0%（9/31）,steady progress （SD） of 41.9% （13/31） and promotion progress （PD） of 19.4% （6/31）.The median time to progression （TTP） was 5.9 months and median survival time （MST） was 10.7 months.The total response rates were 70% for newly diagnosis patients and 23.8% for recurrence patients.The main ADR were neurotoxicity （89.1%）,leukopenia （82.6%）,nausea/vomiting （72.8%） and alopecia （66.3%）.None of chemotherapy-related death occurred.CONCLUSION：Paclitaxel combined with oxaliplatin and 5-Fu POF regimen appears to be effective and tolerated in the treatment of advanced gastric cancer.

关 键 词：紫杉醇 奥沙利铂 5-氟尿嘧啶 胃癌 进展期 疗效 不良反应 

分 类 号：R917[医药卫生—药物分析学]