我院2009年抗癫痫药物血药浓度监测结果分析  

Analysis of Serum Concentration of Anti-epileptic in 2009

作　　者：郭玉娇[1] 王蔚青[1] 邵志高[1] 赵萍[1] 张宏文[1] 

机构地区：[1]南京医科大学第一附属医院,南京市210029

出　　处：《中国药房》2010年第28期2658-2660,共3页China Pharmacy

摘　　要：目的:促进临床合理应用抗癫痫药物并提高其疗效。方法:回顾性分析我院2009年门诊或住院患者服用丙戊酸(VPA)、卡马西平(CBZ)、苯妥英钠(PHT)的487例癫痫患者的血药浓度监测结果。结果:487例监测中,248例(50.92%)在有效血药浓度范围内;177例(36.34%)低于有效血药浓度;51例(10.47%)高于有效血药浓度;11例(2.26%)未检出血药浓度。其中,在有效血药浓度范围内的3种药物比例分别是VPA(48.18%)、CBZ(74.29%)、PHT(10.87%)。结论:抗癫痫药物的血药浓度监测为临床设计个体化给药方案提供了依据,是保证安全、有效用药的重要措施。OBJECTIVE：To promote the clinical application and improve the curative effect of serum concentration.METHODS：In a retrospective review,the serum drug concentrations of 487 outpatients and inpatients of our hospital treated with 3 kinds of anti-epileptics included valproic acid,phenytoin and carbamazepine were analyzed.RESULTS：Among 487 samples,there were 248 cases（50.92%） whose serum concentration were in normal range,177 cases （36.34%） in low range and 51 cases（10.47%） in high range.Also,there were 11 cases（2.26%） whose serum concentration could not be monitored.The percentage of patients treated with valproic acid,carbamazepine and phenytoin whose serum concentrations in normal range were 48.18%,74.29% and 10.87%.CONCLUSION：The serum concentration monitoring of Anti-epileptic is the important measure which provide the basis for adopting individualized administration and ensures the clinical effect and safety in the medical care.

关 键 词：癫痫 血药浓度 监测 丙戊酸 卡马西平 苯妥英钠 

分 类 号：R917[医药卫生—药物分析学]