灵芝多糖对2型糖尿病大鼠模型的治疗作用  

Therapeutic effects of Ganoderma Polysaccharide on type 2 diabetes in rats

作　　者：曹慧[1] 郭秀珍[2] 

机构地区：[1]兰州军区总医院药材科 [2]兰州军区总医院保健一部,甘肃兰州730050

出　　处：《现代生物医学进展》2010年第12期2256-2258,共3页Progress in Modern Biomedicine

摘　　要：目的:研究灵芝多糖对链脲佐菌素诱导的2型糖尿病大鼠降糖降脂作用。方法:采用高糖高脂饲料喂养4周后,腹腔注射链脲佐菌素诱导建立2型糖尿病大鼠模型,分组给予不同剂量灵芝多糖4周,观察血糖及血生化指标。结果:灵芝多糖三个剂量组降糖作用显著,随着剂量增大,降糖作用增强,且均能显著降低胆固醇和低密度脂蛋白;与阳性对照药物相比,灵芝多糖各剂量组降低血脂作用均弱于格列本脲。结论:灵芝多糖对STZ诱导的2型糖尿病大鼠有一定的降低血糖、胆固醇和甘油三酯作用。Objective：To investigate the hypoglycemic and hypolipidemic effects of Ganoderma Polysaccharide in rats with STZ-induced type 2 diabetes.Methods：Type 2 diabetes was induced by injection of streptozotocin（STZ）（ip） in rats after high·fat and high·sugar diet given for 4 weeks.The changes of blood glucose and other biological indexes were assessed after 4 weeks in the rats treated with Ganoderma Polysaccharide for 4 weeks.Results：Ganoderma Polysaccharide notably reduced blood glucose in a dose-dependent manner.It also decreased cholesterol and low density lipoprotein.However,the effects of Ganoderma Polysaccharide was weaker than that of glibenclamide,the positive control agent.Conclusions：The data indicate that Ganoderma Polysaccharide has hypoglycemic and hypolipidemic effects in rats with STZ-induced type 2 diabetes.

关 键 词：灵芝多糖 糖尿病 血糖 

分 类 号：Q95-3[生物学—动物学] R587.1[医药卫生—内分泌]