凝聚法制备川芎嗪固体脂质纳米粒  

Preparation of TMP Solid Lipid Nanoparticles by Coagulation

作　　者：郝存江[1] 饶卫兵[1] 魏丽[1] 舒乐新[2] 刘志东[2] 杨梦婕[1] 

机构地区：[1]天津中医药大学天津市中药化学与分析重点实验室,天津3001932 [2]天津中医药大学中医药研究院,天津300193

出　　处：《现代生物医学进展》2010年第12期2349-2351,共3页Progress in Modern Biomedicine

摘　　要：目的:制备川芎嗪固体脂质纳米粒。方法:采用凝聚法制备,并以包封率和载药量为指标采用正交设计法优化川芎嗪固体脂质纳米粒的制备工艺,并利用透射电镜、激光粒度分析仪、Zeta电位测定仪表征了其药剂学性质。结果:所得川芎嗪固体脂质纳米粒的最佳制备处方是川芎嗪45mg,卵磷脂600mg,硬脂酸450mg,0.4%的泊洛沙姆60ml。结论:该处方可用于川芎嗪固体脂质纳米粒的制备,工艺简单、可行。Objective：To prepare TMP solid lipid nanoparticles.Methods：TMP solid lipid nanoparticles were prepared by coacervation method,And the optimum formula was selected through orthogonal design test according to the entrapment efficiency and drug-loading rate,and Transmission electron microscopy,laser particle size analyzer,zeta potential measurement instruments were used to characterize the nature of its pharmacy.Results：The results showed that the suitable prescription consisted of TMP 45mg,lecithin 600mg,stearic acid 450mg,0.4% of the poloxamer 60ml.Conclusion：The preparation technology of TMP solid lipid nanoparticles by coacervation method was feasible.

关 键 词：川芎嗪 固体脂质纳米粒 凝聚法 

分 类 号：R917[医药卫生—药物分析学]