潜在放射性药物—镓环多胺多羧酸类配合物研究进展  

Development of research on potential radiopharmaceuticals-gallium cyclic polyamines polycarboxylic acids complexes

作　　者：江雪清[1] 王明召[2] 

机构地区：[1]贵州师范学院化学与生命科学学院,贵州贵阳550018 [2]北京师范大学化学学院,北京100875

出　　处：《贵州师范学院学报》2010年第6期24-29,共6页Journal of Guizhou Education University

摘　　要：综述了镓标记的环多胺多羧酸类配合物作为潜在放射性药物的研究进展。其中NOTA类镓螯合物热力学和动力学稳定性高,使放射性药物在体内保持完整;双功能连接剂DOTA类镓螯合物可与生物分子共轭,其标记物的药用特性尤为突出,是环多胺多羧酸类镓放射性药物的研究重点。The development of research on gallium labeled cyclic polyamines polycarboxylic acids complexes as potential radiopharmaceuticals are introduced in the review.Gallium NOTA complexes have high thermodynamics and kinetics stability,so the radiopharmaceuticals remain intact in vivo.Bifunctional coupling agents DOTA gallium complexes can be conjugated to biomolecule and the medical property is very good,which is the research focus of gallium cyclic polyamines polycarboxylic acids radiopharmaceuticals.

关 键 词：镓环多胺多羧酸配合物 放射性药物 NOTA DOTA 

分 类 号：O615.42[理学—无机化学]