基因多态性在儿童原发性肾病综合征中的临床意义  

The clinical significance of gene polymorphism in children＇s primary nephrotic syndrome

作　　者：陈娟(综述)[1] 鹿玲(审校)[1] 

机构地区：[1]安徽医科大学第一附属医院儿科,合肥230032

出　　处：《国际儿科学杂志》2010年第4期393-395,共3页International Journal of Pediatrics

摘　　要：儿童原发性肾病综合征（PNS）的发病机制目前尚未完全明确.近年来研究显示,某些基因如血管紧张素转换酶基因、载脂蛋白E基因、血小板活化因子水解酶基因、人类白细胞抗原基因、糖皮质激素受体基因、细胞因子基因等的多态性与PNS的易患性、病理进展、激素疗效、疾病复发及预后明显相关,该文就与PNS有关的基因多态性的研究进展作一综述.The pathogenesis of children＇s primary nephrotic syndrome has not been completely clear at present.In the past few years,The polymorphism of these genes,such as angiotensin-converting enzyme gene,apolipoprotein E gene,platelet-activating factor acetylhydrolase gene,human histocompatibility leukocyte antigen gene,glucocorticoid receptor gene and cytokine gene,ect have been discovered that were significantly correlated with susceptibility,pathological progress,steroid response,disease recurrence and prognosis of primary nephrotic syndrome.This article reviewed the research progress of PNS and gene polymorphism.

关 键 词：儿童 肾病综合征 基因 多肽现象(遗传学) 

分 类 号：R692[医药卫生—泌尿科学]