Smac／DIABLO与急性肾缺血再灌注性损伤  

Smac/DIABLO and acute renal ischemia-reperfusion injury

作　　者：花兵(综述)[1] 董文斌(审校)[1] 

机构地区：[1]泸州医学院附属医院新生儿科,646000

出　　处：《国际儿科学杂志》2010年第4期403-405,共3页International Journal of Pediatrics

基　　金：基金项目：四川省杰出青年学科带头人培养基金资助项目（04ZQ026-033）

摘　　要：缺血再灌注是新生儿窒息后肾损伤的关键因素,可导致肾小管上皮细胞凋亡.细胞凋亡是窒息后肾小管上皮细胞损伤的重要形式.凋亡信号刺激时,Smac/DIABLO的线粒体定位信号肽被切除,能够从线粒体释放到胞质,与凋亡抑制蛋白特异性结合,解除凋亡抑制因子对半胱氨酸蛋白酶（caspase）的阻碍作用,激活各级caspase引起级联反应,从而促进凋亡发生,加重缺血再灌注肾损伤,导致急性肾功能衰竭.Ischemia-reperfusion after neonatal asphyxia is a key factor in renal injury,which often leads to apoptosis of tubular epithelial cells.Apoptosis is an important form of injury for renal tubular epithelial cells after asphyxia.Smac/DIABLO is released to the cytosol in response to diverse apoptotic stimuli while mitochondrial targeting signal peptide is removed.In the cytosol,Smac/DIABLO interacts and antagonizes inhibitors of apoptosis proteins,thus allowing the activation of caspases and apoptosis.And thus it increases the ischemia-reperfusion renal injury,leading to acute renal failure.

关 键 词：SMAC/DIABLO 凋亡抑制蛋白 细胞调亡 肾脏 缺血再灌注性损伤 

分 类 号：R658.3[医药卫生—外科学]