广州市1992～2007年乙型肝炎疫苗接种率与发病趋势分析  

Hepatitis B Vaccine Coverage and Hepatitis B Morbidity Trend in 1992～2007 in Guangzhou City,China

作　　者：李志群[1] 王鸣[1] 许建雄[1] 蔡衍珊[1] 刘建华[1] 陈健[1] 冯小娥[1] 

机构地区：[1]广州市疾病预防控制中心,广州510080

出　　处：《中国生物制品学杂志》2010年第7期730-733,共4页Chinese Journal of Biologicals

摘　　要：目的分析广州市1992~2007年乙型肝炎疫苗接种率与发病趋势,为乙肝免疫和防治策略提供依据。方法对广州市1992~2007年出生的儿童乙肝疫苗接种率及乙肝发病率进行调查。结果接种初期（1992~1994年）疫苗接种率为63.14%,接种后期（2002~2007年）为95.72%。1992~2007年1~16岁年龄组乙型肝炎发病13699例,总发病率在（26.21~122.74）/10万之间,其中接种初期发病率最高,为122.74/10万,接种后期最低,为26.21/10万,下降了78.65%。1~5岁、6~10岁和11~16岁组乙肝发病呈逐年下降趋势,降幅分别为54.82%,75.04%和83.04%。接种后期与接种初、中（1995~2001年）期比较,HBsAg阳性率分别下降了80.80%和79.13%,抗-HBs阳性率分别升高了8.70%和13.15%,抗-HBc阳性率分别下降了23.24%和4.29%。结论广州市推广新生儿乙肝疫苗接种已取得良好效果。Objective To analyze the hepatitis B（HB）vaccine coverage and HB morbidity trend 1992 ~ 2007 in Guangzhou City,China and provide a basis for the strategy of prevention and treatment of HB.Methods The coverage of HB vaccine as well as morbidity of HB in the children born in 1992 ~ 2007 in Guangzhou were investigated.Results The coverages of HB vaccine in 1992 ~ 1994 and 2002 ~ 2007 were 63.14% and 95.72% respectively.A total of 13 699 patients with HB,at ages of 1 ~ 16 years,were reported in 1992 ~ 2007,indicating a morbidity ranged from 26.21 /100 000 in 2007 and 122.74 /100 000 in 1992,which decreased by 78.65%.The morbidities decreased year by year,of which those in the patients at ages of 1 ~ 5,6 ~ 10 and 11 ~ 16 years decreased by 54.82%,75.04% and 83.04% respectively.Compared with those in 1992 ~ 1994 and 1995 ~ 2001,the HBsAg positive rate in 2002 ~ 2007 decreased by 80.80% and 79.13%,while anti-HBs positive rate increased by 8.70% and 13.15%,and anti-HBc positive rate decreased by 23.31% and 4.29%,respectively.Conclusion The popularization of HB vaccine in newborns in Guangzhou City showed satisfactory effect.

关 键 词：肝炎 乙型 疫苗 免疫 接种率 发病率 

分 类 号：R512.62[医药卫生—内科学] R186[医药卫生—临床医学]