47例系统性红斑狼疮患者死亡因素分析  

Analysis of death causes in 47 patients with systemic lupus erythematosus

作　　者：孙甲峰[1] 李向培[1] 陶金辉[1] 厉小梅[1] 汪国生[1] 张宏[1] 李冬梅[1] 

机构地区：[1]合肥安徽医科大学附属省立医院风湿免疫科,230001

出　　处：《安徽医学》2010年第7期768-770,共3页Anhui Medical Journal

摘　　要：目的研究分析系统性红斑狼疮(SLE)患者死亡相关因素。方法回顾性收集SLE死亡患者47例,同期住院患者94例,对死亡相关因素进行对比分析。结果死亡组发热、肺部感染、神经精神症状、狼疮肾炎的发生率高于存活组(P<0.05);SLEDAI评分高于存活组(P<0.05)。两组间贫血、血小板、ANA及抗Sm抗体、谷丙转氨酶、谷草转氨酶差异有统计学意义(P<0.05)。结论 SLE患者死亡与疾病活动密切相关;多脏器损害合并感染是导致死亡的危险因素。Objective To analyze factors associated with the death of patients with systemic lupus erythrmatosus（SLE）.Methods The data of 47 cases died of SLE and 94 survivors in patients with SLE were analyzed retrospectively.Results Compared with the survival group,the incidence of fever,lung infection,neuropsychiatric symptoms,lupus nephritis and SLEDAI score in death group increased significantly（P〈0.05）.Anemia,thrombocytopenia and hypoproteinemia,ANA and anti-Sm antibody positive,alanine,aspartate aminotransferase elevation were significantly different between the two groups（P〈0.05）.Conclusion Mortality in SLE patients were closely related to disease activity and infection;multiple organ damage with infenction was an important risk factor for death.

关 键 词：红斑狼疮 系统性 死亡因素 

分 类 号：R593.241[医药卫生—内科学]