孕妇HBV感染状态与垂直传播关系的研究  

Relationship Between the HBV Infectic State of Pregnant Woman and Vertical Transmission

作　　者：李跃珍[1] 王悦娥[1] 王美[1] 

机构地区：[1]潍坊市人民医院

出　　处：《山东医药》1999年第5期16-17,共2页Shandong Medical Journal

摘　　要：用聚合酶链反应（ＰＣＲ－ＥＢ）技术，对ＨＢｓＡｇ阳性孕妇７８例（实验组）和ＨＢｓＡｇ阴性孕妇４３例（对照组）的血清、脐血和乳汁中的ＨＢＶ－ＤＮＡ进行检测，同时用酶联免疫吸附法（ＥＬＩＳＡ）检测两组孕妇血清ＨＢＶ标志物，结合孕妇感染状态做相关性分析。结果：实验组血清ＨＢＶＤＮＡ检出率为５１．３％，对照组未检出，两组有极显著性差异（Ｐ＜０．００１）。实验组乳汁、脐血中ＨＢＶ－ＤＮＡ阳性率分别为２９．５％、３９．７％，对照组未检出，两组有极显著性差异（Ｐ＜０．００１）。HBV DNA in serum,cord blood and milk of 78 HBsAg positive pregnant women(experimental group)and 43 HBsAg negtive pregnant women(control group)was tested by polymerase chain reaetion(PCR),while the marking products of hepatitis B virus(HBV)in serum were also detected by ELISA The correlative analysis in conjunction with infectic state of pregnant women showed that the present rate of HBV DNA positive serum,cord blood and milk of experimental group was 51 3%,29 5% and 39 7% respectively and none in control group There was a significant difference in the two groups(P<0 001) The result suggested that there was a relationship between the infectic state and HBV DNA positive rate in pregnant women and vertical transmission

关 键 词：孕妇 乙型肝炎病毒 聚合酶链反应 垂直传播 

分 类 号：R714.251[医药卫生—妇产科学] R512.62[医药卫生—临床医学]