卡马西平和左乙拉西坦单药治疗儿童部分发作性癫痫的对照研究  

Control Study for Carbamazepine and Levetiracetam in Treating Children with Partial Epilepsy as Monotherapy

作　　者：黄铁栓[1] 朱金兰[1] 

机构地区：[1]广东省深圳市儿童医院,广东深圳518026

出　　处：《儿科药学杂志》2010年第4期25-27,共3页Journal of Pediatric Pharmacy

摘　　要：目的:比较卡马西平和左乙拉西坦单药治疗儿童部分发作性癫痫的疗效。方法:53例在我院新诊断的部分发作性癫痫儿童,根据就诊顺序按单双号顺序分成两组,分别给予卡马西平和左乙拉西坦单药治疗,左乙拉西坦起始剂量10mg/(kg.d),每周加量一次,逐渐加量至20～30mg/(kg.d),最大剂量40mg/(kg.d);卡马西平起始剂量5mg/(kg.d),每周增加5mg/(kg.d),逐渐增加剂量至10～20mg/(kg.d)。血药浓度6～10mg/L。随访6月后评价疗效及不良反应。结果:53例全部完成观察和随访,卡马西平组26例,左乙拉西坦组27例。卡马西平组15例完全控制发作(57.7%),4例部分控制(15.4%),总有效率为73.1%;左乙拉西坦组10例完全控制发作(37.0%),5例部分控制(18.5%),总有效率为55.5%。两组总有效率比较差异无统计学意义(P>0.05)。两组均未见严重不良反应。结论:左乙拉西坦和卡马西平单药治疗儿童部分发作性癫痫均有很好疗效和耐受性。Objective：To compare the efficacy of carbamazepine and levetiracetam in treating pediatric partial seizures as first-line monotherapy.Methods：Fifty-three children with partial seizures were enrolled and evaluated.They had more than one seizure per month for three months before treatment and were diagnosed by typical seizures and video-EEG recording.These eligible patients were divided into two groups and treated with carbamazepine（CBZ）or levetiracetam（LEV）.The initial dosage of LEV was 10 mg/（kg·d）.It was gradually increased and the maintenance dosage was 20-30 mg/（kg·d）and would not exceed the maximum dosage of 40 mg/（kg·d）.The initial dosage of CBZ was 5 mg/（kg·d）,and it was weekly increased by 5 mg/（kg·d）to the dosage of 10-20 mg/（kg·d）as the maximum or till a plasma concentration of 6-10 mg/L was obtained.All patients had at least been followed up for six months.Results：Fifty-three children completed the study,27 children taking LEV while 26 taking CBZ.Fifteen children（57.7%）were seizure-free in the group with CBZ,and in the LEV-treated group,the number was ten（37.0%）.No severe adverse effects were found among all patients.Conclusions：Both CBZ and LEV are efficacious for child partial seizures.

关 键 词：卡马西平 左乙拉西坦 部分发作 癫痫 儿童 

分 类 号：R971.6[医药卫生—药品]