循证护理在儿童白血病大剂量甲氨蝶呤化疗中的应用  

Application of evidence-based nursing on chemotherapy with high-dose methotrexate in leukemia children patinet.

作　　者：王晓敏[1] 颜金花[1] 

机构地区：[1]四川省人民医院,610072

出　　处：《护理实践与研究》2010年第17期28-30,共3页Nursing Practice and Research

摘　　要：目的:探讨循证护理在预防儿童急性淋巴细胞白血病大剂量甲氨蝶呤(MTX)化疗所致毒性反应中的效果。方法:将62例进行大剂量甲氨蝶呤化疗的急性淋巴细胞白血病患儿随机分为实验组(32例)和对照组(30例)。实验组采用循证护理,找出急待解决的问题,实施具体护理措施;对照组接受儿科血液病常规护理。观察两组患儿甲氨蝶呤所致毒副作用发生的情况。结果:实验组口腔黏膜溃疡、消化道反应、肛周感染、肝肾功损害、感染、出血、骨髓抑制发生率均显著低于对照组(P<0.05)。结论:循证护理应用于白血病患儿的大剂量甲氨蝶呤化疗护理中,能有效降低甲氨蝶呤的毒副反应的发生率,提高护理质量及化疗效果。Objective：To explore the effect of evidence-based nursing on the prevention toxic effect of childhood acute lymphoblastic leukemia treatment with high-dose methotrexate chemotherapy.Methods：62 patients with the high-dose methotrexate chemotherapy for acute lymphoblastic leukemia were randomly divided into experimental group （32 cases） and control group （30 cases）.Experimental group used the concept of evidence-based nursing and to identify problems to be solved,and the specific nursing interventions.In the control group received routine care pediatric blood,after the end of treatment due to side effects were observed with methotrexate happened. Results： The occur rate of oral mucosa ulcers,gastrointestinal reaction,perianal infection,infection of liver and kidney function,infection,bleeding,the incidence of bone marrow suppression in experimental group were significantly lower than the control group （P0.05）.Conclusion：The evidence-based nursing applied to leukemia in children with high-dose methotrexate chemotherapy nursing can reduce the incidence of toxicity and improve quality of care and the effect of chemotherapy.

关 键 词：白血病 甲氨蝶呤 循证护理 化疗 

分 类 号：R473.73[医药卫生—护理学]