呼吸病区2003～2008年抗菌药物使用量与铜绿假单胞菌耐药相关性的研究  

Analysis of Correlation between Consumption of Anti-bacterial Agents and Resistance Rate of Pseudomonas Aeruginosa in Respiratory Unit

作　　者：杨新云[1] 卓超[2] 叶枫[2] 钟淑卿[2] 袁锦屏[2] 杨灵[2] 

机构地区：[1]广州医学院第一附属医院药学部,广东广州510120 [2]广州呼吸疾病研究所,广东广州510120

出　　处：《今日药学》2010年第7期37-39,66,共4页Pharmacy Today

基　　金：广州市卫生局基金资助(编号:2006-YB-158)

摘　　要：目的探讨2003～2008年呼吸病区抗菌药物使用与铜绿假单胞菌(PA)耐药水平变化之间的关系。方法计算10种抗菌药物平均每日每百张床位所消耗的DDDs及同期PA的耐药率,并对抗菌药物用量与耐药率进行相关性分析。结果头孢他啶及头孢哌酮/舒巴坦DDDs分别与铜绿假单胞菌对哌拉西林、哌拉西林/他唑巴坦、头孢哌酮/舒巴坦、亚胺培南、环丙沙星、阿米卡星耐药率的相关性有统计学意义,其他组数据无统计学意义。结论呼吸病区头孢他啶及头孢哌酮/舒巴坦DDD s的使用量与PA耐药率有统计学意义。Objective To investigate the relationship between administration of anti-bacterial agents and resistance rate of Pseudomonas aeruginosa（PA） in the respiratory unit. Methods The defined daily doses（DDD） /day/100 bed of the 10 kinds of anti-bacterial was calculated;and the resistance rate of PA at that period was collected;and their correlation was analyzed.Results There was a significant positive correlation between the consumption of ceftazidime cefoperazone-Sulbactam and the resistance rate of PA of ceftazidime,cefoperazone-sulbactam,imipenem,ciprofloxacin,and amikacin.Conclusion There is a significant correlation between the consumption of anti-bacterial agents and resistance rate of PA in the respiratory unit.

关 键 词：铜绿假单胞菌 耐药率 抗菌药物使用频度 

分 类 号：R978[医药卫生—药品]