系统性红斑狼疮患者妊娠对胎、婴幼儿的影响  

Influence of systemic lupus erythematosus complicating regnancy on fetus and infants

作　　者：张惠英[1,2] 洪素英[1,2] 潘伟芬[1,2] 陈顺乐[1,2] 连明 

机构地区：[1]上海第二医科大学附属仁济医院 [2]上海市青浦县中心医院

出　　处：《上海医学》1999年第3期157-159,共3页Shanghai Medical Journal

摘　　要：目的探讨系统性红斑狼疮（ＳＬＥ）患者妊娠对胎、婴儿影响和幼儿智力发育状况影响。方法对８０例ＳＬＥ妊娠的临床资料作前瞻性分析，分析新生儿存活情况，４５例幼儿采取ＤＤＳＴ筛选智能。结果８０例ＳＬＥ孕妇获婴儿８１例（双胎１例），均存活。１８个月至７岁半幼儿共４５例进行ＤＤＳＴ筛选，其中智力异常２例（０．４％）。结论妊娠期间强的松适量口服及妊娠期ＳＬＥ恶化时增加剂量和干预性早产是降低围产儿死亡的关键。ＳＬＥ妊娠与正常妊娠的幼儿智力异常分别为０．４％及０．８％，二者无统计学差异。Objective To estimate the effect of SLE complicating pregnancy on fetus and infanst and on their intelligence development. Methods To carry out a prospective analysis on viability of neonates in 80 pregnant women compelicated by SLE and compare their intelligence development with those of 45 newborn infants using Denven development screening test (DDST). Results 81 viable neonates were delivered by 80 gravid suffering from SLE.(one of these patients gave birth to a twin) 45 infants' intelligence from 18 month old to 7.5 year old were tested by DDST. Two of them were abnormal (The abnormal rate was 0.4%). Conclusions Using suitable dosage of prednisone when SLE complicates poregnancy and increasing the dosage of prednisone when the disease becomes worse is the key measure of reducing the perinatal morbidity. The rate of infants' abnormal intelligence development in SLE complicating pregnancy is 0.4%, where as in normal pregnancy it is 0.8%, There is no statistical difference between the two.(Shanghai Med J, 1999,22:157 159)

关 键 词：系统性红斑狼疮 妊娠 丹佛智能筛选 智力发育 

分 类 号：R714.25[医药卫生—妇产科学] R593.241[医药卫生—临床医学]