HBVe抗原抗体系统与丁型肝炎病毒感染的关系研究  

The relationship between e antigen-antibody system of HBV and HDV infections

作　　者：姚春斓[1] 顾琳[1] 彭晓谋[1] 谢冬英[1] 

机构地区：[1]中山医科大学附属第三医院传染病科,510630

出　　处：《广东医学》1999年第4期256-257,共2页Guangdong Medical Journal

摘　　要：目的　探讨HBVe抗原抗体系统与丁型肝炎病毒感染的关系。方法　将 667例乙肝表面抗原(HBsAg)阳性患者分成e抗原 (HBeAg)阳性、抗 -HBe阳性和两者均阴性等三组进行丁型肝炎病毒 (HDV)标志物的检测和分析。结果　 667例乙肝患者HDV感染 4 3例 ( 6 4 % ) ,其中HBeAg阳性组为 5 3 % ( 11/ 2 0 6) ,抗 -HBe阳性组为 10 9% ( 2 6/ 2 3 7) ,e抗原抗体均阴性组HDV为 2 3 % ( 6/ 2 2 5 )。抗 -HBe阳性组HDV感染明显升高 (P <0 0 1)。HBV从HBeAg阳性向抗 -HBe转换过程伴有HDV从HDAg阳性向抗 -HD抗体的转化。结论　HBV重叠感染HDV时 ,HDV感染或复制具有促进抗 -HBe转化的作用。同时HBV对HDV的复制也存在干扰作用。Objective To study on the relationship between e aitigen-antibody system of HBV and HDV infections. Methods HDV serum markers were detected in 667 cases of patients with positive HBsAg. These cases were divided into three groups according to the e antigen-antibody system. The detective rates of HDV marker were compared among these three groups.Results HDV incidence of these groups of patients was 6.4% (43/667).The detective rates of HBeAg positive group, anti-HBe positive group and both negative group were 5.3% (11/206), 10.9% (26/237) and 2.3%(6/255) respectively. The detective rate of anti-HBe positive group was significantly higher than those of the rest two groups ( P <0 01). The transversion of HBV from HBeAg to anti-HBe was accompanied with the transversion of HDV from HDAg to anti-HD.Conclusion HDV infection might promote the transversion of anti-HBe when HBV infection patients were superinfected by HDV. HBV might interfere in the replication of HDV simulataneously.

关 键 词：乙型肝炎病毒 丁型肝炎病毒 HBVe抗原 

分 类 号：R512.602[医药卫生—内科学]