小鼠高尿酸血症模型初探  

Preliminary Studies on Animal Models of Hyperuricemic Mice

作　　者：金沈锐[1] 郑军[1] 刘绍唐 

机构地区：[1]成都中医药大学基础医学院

出　　处：《成都中医药大学学报》1999年第1期49-50,共2页Journal of Chengdu University of Traditional Chinese Medicine

摘　　要：目的：探索建立小鼠高尿酸血症模型的方法。方法：使用黄嘌呤６００ｍｇ／ｋｇ和乙胺丁醇２５０ｍｇ／ｋｇ，次黄嘌呤６００ｍｇ／ｋｇ和烟酸１００ｍｇ／ｋｇ，ｉｇ给药连续５天。结果：给药两组与正常对照组之间，小鼠血尿酸有显著性差异（Ｐ＜０．０５）。以黄嘌呤和乙胺丁醇组更为明显。结论：提示该两种方法可作为小鼠高尿酸血症动物模型。SUMMARY:Purpose: In search of procedures to establish hyperuricemic mice animal models. Way: Using xanthine (600mg/kg) and ethambutol (250mg/kg), hypoxanthine (600mg/kg) to i.g. mice for 5 ays. Result: The animal models of hyperuricemic mice were gotten. Conclusions: These hyperuricemic mice may be serve as animal models for hyperuricemia.

关 键 词：痛风 高尿酸血症 小鼠 动物模型 

分 类 号：R589.7[医药卫生—内分泌] R695[医药卫生—内科学]