中国儿童1型糖尿病发病率的研究  

Incidence of childhood type 1 diabetes mellitus in China

作　　者：王克安[1] 李天麟[1] 李新华[1] 杨泽[2] 魏一大[1] 颜纯[3] 刘尊永[1] 倪桂臣[3] 金书香[1] 陈泓[1] 秦汝莉[1] 李彦琴[1] 李玉瑞[1] JANICE S.DORMAN RONALD E.LAPORTE 

机构地区：[1]中国预防医学科学院 [2]卫生部老年医学研究所 [3]北京市儿童医院 [4]美国ＰＩＴTＳＢＵＲＧＨ大学流行病学系

出　　处：《中华内分泌代谢杂志》1999年第1期3-7,共5页Chinese Journal of Endocrinology and Metabolism

基　　金：国家自然科学基金;美国NIH部分资助

摘　　要：目的研究我国儿童１型糖尿病的发病率。方法中国预防医学科学院ＷＨＯＤｉａＭｏｎｄ项目中国协调中心在全国建立了登记网络。１６个省、市和自治区的２０个地区根据该中心的计划和要求，对１９８８～１９９６年期间诊断的＜１５岁的１型糖尿病病例进行了回顾性的登记。该研究覆盖＜１５岁儿童１９００余万，登记到我国九个民族，共发现８８３例１型糖尿病病人。结果显示该时期总的确定校正发病率为０．５９／１０万人年〔９５％可信区间（ＣＩ）：０．５７～０．６０〕，其中男０．５２／１０万人年（９５％ＣＩ：０．５０～０．５４），女０．６６／１０万人年（９５％ＣＩ：０．６４～０．６８）。按１９９０年全国人口构成比例标化的确定校正发病率为０．５７／１０万人年。结论我国儿童１型糖尿病的发病率在逐年上升；发病率随年龄的增长而增加；民族间的发病率差异达１２倍；发病率在不同地区之间呈现明显的南低北高现象。Objective To investigate into the incidence rate (IR) of childhood type 1 diabetes mellitus in China. Methods A nationwide register networkwas establishedby theWHODiaMondProject China Coordinating Center,ChineseAcademyofPreventive Medicine (CAPM). Coordinated by that center and following the standardized protocol, 20 local centers in 16 provinces, autonomous regions and municipalities of China registered retrospectively the newly diagnosed cases of type 1 diabetes mellitus with onset age<15 years between 1988～1996. Results The population under investigation was more than 19 million, and 883 type 1 diabetes mellitus from 9 nationalities were registered. The overall ascertained and corrected type 1 diabetes IR was 0.59 per 100000 person year. ThegenderspecificIRswere0.52/100000 (95% CI: 0.50～0.54) for males and 0.66/100000 (95% CI:0.64～0.68) for females. The standard ascertained and corrected IR according to the national age specific population in 1990 was 0.57 per 100000 person year, which was the lowest rate ever reported by other countries. Conclusions The IRs of childhood type 1 diabetes mellitus in China were increasing with passage of time; the age specific IRs increased with age; the various ethnic groups had over a 12 fold difference in IR; and the overall IR was significantly higherin north China than in south regions.

关 键 词：糖尿病 Ⅰ型 流行病学 发病率 儿童 

分 类 号：R725.871[医药卫生—儿科]