雷公藤多甙与DC单抗对小鼠自身免疫性甲状腺炎作用的研究  

EFFECTS OF TRIPTERYGIUM WILFORDII POLYGLYCOSI DIUM AND ANTI DENDRITIC CELL McAb ON AUTOIMMUNE THYROIDITIS IN MOUSE

作　　者：王胜军[1,2] 许化溪[1,2] 江淑芳 柳龙图[1,2] 刘恭植[1,2] 

机构地区：[1]镇江医学院免疫学研究室 [2]南京81医院

出　　处：《免疫学杂志》1999年第2期101-102,共2页Immunological Journal

基　　金：江苏省教委资助

摘　　要：在建立小鼠自身免疫性甲状腺炎（ＡＩＴ）的基础上，研究雷公藤多甙和树突状细胞（ＤＣ）单克隆抗体对诱导小鼠ＡＩＴ的影响。结果表明，经雷公藤多甙、ＤＣ单抗单独及联合应用后，与未用药组相比，血清中ＴｇＡｂ水平、Ｔｇ刺激的淋巴细胞增殖能力、脾淋巴细胞产生ＴＮＦ水平均显著降低（Ｐ＜０．０５），其中以联合应用组尤为明显，病理学检查亦与之相符。提示雷公藤多甙、ＤＣ单抗的应用对小鼠ＡＩＴ的发生具有抑制作用。In this paper,the autoimmune thyroiditis(AIT)of mice was used as an experimental model,and the effects of tripterygium wilfordii polyglycosidium(TWP)and anti DC McAb on AIT were studied.The results showed that the levels of thyroglobulin antibody,the proliferation of lymphocytes stimulated by thyroglobulin and the levels of tumor necrosis factor were significantly decreased in the TWP or anti DC McAb group,( P <0.05) especially in the TWP administered Anti DC McAb group.Pathologic observation also proved these results .It was suggested that TWP and anti DC McAb had immunosuppressive effect on AIT.

关 键 词：雷公藤多甙 树突状细胞 单克隆抗体 甲状腺炎 

分 类 号：R581.405[医药卫生—内分泌] R979.5[医药卫生—内科学]