铁屎米酮对大鼠心肌缺血再灌注损伤的保护作用  

PROTECTIVE EFFECT OF CANTHIN 6 ONE ON MYOCARDIAL ISCHEMIA REPERFUSION INJURY IN RATS

作　　者：石明健[1,2] 刘惟莞[1,2] 胡岚 王红英[1,2] 杨晓茹[1,2] 余恩欣 

机构地区：[1]湖北医科大学药理教研室 [2]湖北省药品检验所

出　　处：《药学学报》1999年第3期161-163,共3页Acta Pharmaceutica Sinica

基　　金：中国科学院资源与环境研究"九五"重大项目"治疗数种重要疾病新天然药物的研究与开发"专题基金

摘　　要：目的：研究铁屎米酮对心肌缺血再灌注损伤的保护作用。方法：大鼠左冠脉前降支结扎造成心肌缺血再灌注损伤。结果：铁屎米酮（５，１０及２０ｍｇ·ｋｇ－１，ｉｇ）可显著降低缺血再灌性心律失常发生率，缩短心律失常持续时间，防止室颤的发生；减少心肌丙二醛含量，提高心肌超氧物歧化酶活性；减轻心肌细胞超微结构损伤。AIM: To study the effect of canthin 6 one (Can) on myocardial ischemia and reperfusion injury. METHODS: The left coronary artery of the rat was ligated. RESULTS: Can (5, 10, 20 mg·kg -1 , ig) was shown to decrease the incidence of arrhythmia induced by ischemia and reperfusion, shorten the duration of ventricular arrhythmia, eliminate the incidence of ventricular fibrillation; increase the activities of superoxide dismutase (SOD), decrease the malondialdehyde (MDA) contents and alleviate the myocardial ultrastructure injury. CONCLUSION: Can has protective effect on the injury induced by myocardial ischemia and reperfusion.

关 键 词：铁屎米酮 再灌注损伤 心肌缺血 心肌保护 大鼠 

分 类 号：R542.205[医药卫生—心血管疾病] R364.12[医药卫生—内科学]