IV型变态反应中白细胞介素6的表达及白藜芦醇的抑制作用  

AND INHIBITION EFFECTS OF RESVERATROL ON INTERLEUKIN 6 BIOSYNTHESIS

作　　者：李怡棠[1,2] 钟淼[1,2] 邓永江 朱秀媛[1,2] 程桂芳[1,2] 

机构地区：[1]中国医学科学院中国协和医科大学药物研究所 [2]北京军区总医院病理科

出　　处：《药学学报》1999年第3期189-191,共3页Acta Pharmaceutica Sinica

摘　　要：目的：研究白细胞介素６（ＩＬ６）在２，４二硝基氟苯（ＤＮＦＢ）诱导的ＩＶ型变态反应中的表达及不同剂量的白藜芦醇对ＤＮＦＢ诱导的ＩＶ型变态反应中ＩＬ６生成的量效关系，探讨ＩＬ６在免疫性炎症中的作用及白藜芦醇抗炎作用机理。方法：采用免疫组织化学的方法。结果：白藜芦醇皮下给药５０ｍｇ·ｋｇ－１可明显抑制由ＤＮＦＢ诱导的ＩＶ型变态反应中的小鼠耳肿胀，抑制率为７０％。白藜芦醇在皮下给药５０，１００ｍｇ·ｋｇ－１剂量下，可抑制ＤＮＦＢ诱导的ＩＶ型变态反应中ＩＬ６的生成。结论：ＤＮＦＢ诱导的ＩＶ型变态反应确有ＩＬ６的表达。AIM: To study the effects of resveratrol on Interleukin 6 (IL 6) biosynthesis, observe the action of IL 6 in the process of immunoinflammation and investigate the mechanism of the antiinflammation effects of resveratrol. METHODS: Immuno histochemistry was used to detect the levels of IL 6 in delayed type hypersensitivity induced by DNFB(2,4 Dinitrofluorobenzene). RESULTS: In the mouse models of inflammation of delayed type hypersensitivity induced by DNFB, resveratrol was shown to significantly(30%) inhibit the inflammatory response at the dose of 50 mg·kg -1 (sc), and resveratrol, at the doses of 50 and 100 mg·kg -1 (sc) inhibited production of IL 6. CONCLUSION: Resveratrol is a potent antiinflammatory agent and there is IL 6 expression in the mouse model of delayed type hypersensitivity induced by DNFB. The mechanism of actions of resveratrol on antiinflammation may be related with the inhibition of IL 6 biosynthesis.

关 键 词：白藜芦醇 抗炎作用 Ⅳ型变态反应 白细胞介素6 

分 类 号：R971.1[医药卫生—药品] R593.1[医药卫生—药学]