卵巢储备低下患者黄体期补充雌激素对IVF-ET结局的研究  

Effect of adding estradiol for the patients with low ovarian reserve in luteal phase on the outcome of IVF-ET

作　　者：杨嫦玉[1] 熊永崂[1] 罗惜冰[1] 梁伟敏[1] 

机构地区：[1]广东省珠海市妇幼保健院生殖中心,519000

出　　处：《中国妇幼保健》2010年第20期2840-2842,共3页Maternal and Child Health Care of China

基　　金：珠海市科技局项目(编号:PC20081037)

摘　　要：目的:比较黄体期补充雌激素对卵巢低反应患者的影响。方法:60名卵巢低反应患者,30例在促排卵前黄体期给予雌二醇每天2mg,30例给予安慰剂。结果:使用雌二醇的妇女可以获得HCG日较厚的子宫内膜,更高的获卵数(P<0.05),更多的成熟卵母细胞(P<0.05),更高的受精率(P<0.05)和更多的优质胚胎(P<0.01)。两组启动日窦卵泡数、促排卵时间和临床妊娠率差异无统计学意义。结论:卵巢低反应患者促排卵前黄体期补充雌二醇可以提高IVF-ET优质胚胎数目和胚胎质量,增加子宫内膜厚度,从而可能提高妊娠率。Objective：To compare the effect of adding estradiol in luteal phase on the patients with low ovarian reserveMethods：30 patients with low ovarian reserve were given estradiol in luteal phase and 30 patients with low ovarian reserve were given placebo when treated by IVF-ET.Results：Patients given estradiol had thicker endometrium（P0.05）,more aquired oocytes（P0.05）,more matured oocytes（P0.05）,higher fertilization rate （P0.05）and more capably-transferred embryos（P0.01）.There were no significant difference in andral follicles in initiated day,time of controlled ovarian stimulation,total gonadotropin and clinical pregnancy rate.Conclusion：Adding estradiol in luteal phase preceding IVF-ET hyperstimulation can increase the number and quality of embryos for the patients with low ovarian reserve,improve the endometrium.This method may ultimately improve the pregnancy rate in these patients.

关 键 词：卵巢储备低下 黄体期 雌二醇 卵巢反应性 

分 类 号：R711.75[医药卫生—妇产科学]