水红花子对小鼠免疫功能的影响  

Effects of Fructus Polygoni Orentalis on the Immune Function of Mice

作　　者：王红梅 马素好 张娟 

机构地区：[1]郑州澍青医学高等专科学校,河南郑州450064

出　　处：《河南中医》2010年第7期656-658,共3页Henan Traditional Chinese Medicine

基　　金：河南省科技攻关项目(编号:0524420040)

摘　　要：目的:探讨水红花子对小鼠免疫功能的影响。方法:实验组小鼠采用水红花子水煎剂,0.5ml/d,连续灌胃1周,对照组小鼠采用同剂量的生理盐水,连续灌胃1周。测定小鼠淋巴细胞转化率、T淋巴细胞数量、抗体IgM分泌量、单核-巨噬细胞的吞噬活性以及迟发型变态反应(DTH)强度。结果:实验组小鼠脾淋巴细胞的转化率、T淋巴细胞的数量、抗体生成细胞分泌抗体IgM量、单核-巨噬细胞的吞噬活性以及耳朵的肿胀度均明显低于对照组,且差异显著(P<0.01)。结论:水红花子可明显降低小鼠的细胞和体液免疫功能及单核-巨噬细胞的吞噬活性。Objective：To probe into efffect of polygonum orientalis on the immune function of mice.Methods：The experimental group were given gastric perfusion of polygonum orientale decoction,0.5 ml/d,continuously for one week,while the control group with the same dose of saline,continuously for 1 week.Determined the lymphocyte transformation rate,number of T lymphocytes,antibody IgM secretion,phagocytic activity of monocyte-macrophage and hypersensitivity（DTH） intensity of the delayed type.Results：The lymphocyte transformation rate,number of T lymphocytes,antibody IgM secretion,phagocytic activity of monocyte-macrophage,hypersensitivity（DTH） intensity and the ear swelling of the experimental group were significantly lower than those of the control group,and the difference was significant（P 〈0.01）.Conclusion：Polygonum orientale can significantly reduce cellular and humoral immunity and phagocytic activity of monocyte-macrophage.

关 键 词：水红花子 免疫功能 小鼠 

分 类 号：R285.5[医药卫生—中药学]