心血管重塑及其血浆胶原标志物  

Using Circulating Biomarkers of Collagen Metabolism in Cardiovascular Remodeling

作　　者：邓玮[1] 陈庆伟[1] 

机构地区：[1]重庆医科大学附属第二医院老年病科,重庆400010

出　　处：《心血管病学进展》2010年第4期552-555,共4页Advances in Cardiovascular Diseases

摘　　要：众多心血管疾病(如扩张型心肌病、冠心病、心力衰竭等)及其危险因素(糖尿病、肥胖等)涉及心血管重塑和心脏纤维化。胶原及前胶原末端肽、基质金属蛋白酶、基质金属蛋白酶组织抑制剂作为血浆胶原标志物,能协助评估心血管重塑程度及预后。Cardiovascular remodeling and cardiac fibrosis have frequently been observed in relation to manifestations of cardiovascular diseases（dilated cardiomyopathy,coronary artery disease,chronic heart failure） and their risk factors（diabetes,obesity）.Collagen and procollagen peptides,matrix metalloproteinases and tissue inhibitors of metalloproteinases have been recognized as circulating biomarkers of collagen metabolism.The markers of collagen metabolism can be used to evaluate the progress of and the prognosis of cardiovascular remodeling.

关 键 词：心血管重塑 胶原 标志物 

分 类 号：R541.4[医药卫生—心血管疾病]