阿司匹林抵抗相关研究进展  

Defining Mechanism of Aspirin Resistance

作　　者：侯靓亮[1,2] 魏立[1,2] 

机构地区：[1]青岛大学医学院 [2]解放军401医院心血管内科,山东青岛266071

出　　处：《心血管病学进展》2010年第4期595-598,共4页Advances in Cardiovascular Diseases

摘　　要：阿司匹林抵抗描述了导致阿司匹林在预防血栓并发症、引起出血时间延长、体外抑制血小板聚集以及抑制血小板血栓素形成等方面效力降低的多种不同现象。通过生化方法测定,我们将阿司匹林抵抗分为三种不同类型,此种分型有助于阐述阿司匹林抵抗的机制,包括药物剂量不足、血小板周转加快、药物依从性差、相关基因多态性以及血栓素非经血小板旁路途径形成等。Aspirin resistance describes a group of phenomenon which includes：low efficiency in prevention for complication of thrombus,in prolonging bleeding time,in prohibition of platelet aggregation,and in the formation of thromboxane.In accordance with biochemical methods we have classified aspirin resistance into three types which work to explain the aspirin resistance mechanism.Possible causes of aspirin resistance include under dosage of aspirin,increased turnover of platelets,poor compliance,polymorphism of related genes,and up regulation of alternate（non-platelet） pathways of thromboxane production.

关 键 词：阿司匹林抵抗 环氧合酶 血栓素A2 基因多态性 

分 类 号：R971[医药卫生—药品]