三磷酸腺苷与普罗帕酮急诊转律阵发性室上性心动过速随机对照研究  

Adenosine triphosphate and propafenone treat paroxysmal supraventricular tachycardia in emergency room:a randomized controlled trial

作　　者：陈国柱[1] 尤再春[1] 李霞[1] 史忠[1] 

机构地区：[1]第三军医大学新桥医院急救部,重庆400037

出　　处：《重庆医学》2010年第15期2015-2016,2019,共3页Chongqing medicine

摘　　要：目的研究三磷酸腺苷(ATP)与普罗帕酮(propafenone)急诊转律阵发性室上性心动过速(PSVT)的效果。方法选择PSVT患者173例,随机分为ATP组(n=86)及普罗帕酮组(n=87),比较二者的转律成功率、转律时间、不良反应发生率等。结果 ATP与普罗帕酮转律时间分别为(0.92±0.38)min、(33.00±17.00)min(P<0.01);转律成功率分别为97.7%、88.5%(P<0.05);ATP组轻度不良反应发生率大于普罗帕酮组(分别为37.2%、11.5%,P<0.01),普罗帕酮组严重不良反应率大于ATP组(分别为4.6%、1.2%,P<0.05)。结论急诊室环境下应用ATP及普罗帕酮转律PSVT具有较高的成功率。虽然ATP转律有较多的轻度不良反应,但比普罗帕酮成功率及安全性更高。Objective To evaluate the therapy effect of adenosine triphosphate and propafenone to paroxysmal supraventricular tachycardia in emergency room. Methods One hundred and seventy-three patients who were diagnosed paroxysmal supraventricular tachyeardia were randomly separated into group ATP（n=86） and group propafenone（n=87）. The achievement ratio, time. of conversion,side effects of two drugs were compared. Results The time of conversion in group ATP and group propafenone was 0.92± 0.38 minand 33.00±17.00min respectively（P〈0. 01）. The achievement ratio in group ATP was 97. 7% and 88. 5% in group propafenone （P〈0.05）. More mild side effects were recorded in group ATP（ 37.2% vs 11.5%, P〈0.01 ）, whereas more severe side effects were discovered in group propafenone（ 1.6% vs 1.2% ,P〈0. 05）. Conclusion Treat PSVT with ATP or propafenone can get a highly achievement ratio. Although ATP has more mild side effects in cardioversion,it has more safety and more success- ful than propafenone.

关 键 词：三磷酸腺苷 普罗帕酮 室上性心动过速 心律失常 药物治疗 

分 类 号：R541.71[医药卫生—心血管疾病] R972.2[医药卫生—内科学]