血浆病毒灭活后质量回顾性分析  

Plasma component variation after methylene blue virus inactivation treatment

作　　者：王飞[1] 卢舜华[1] 叶小演[1] 王桂萍[1] 古醒辉[1] 

机构地区：[1]深圳市血液中心,518035

出　　处：《重庆医学》2010年第15期2043-2044,共2页Chongqing medicine

基　　金：深圳市科技局课题资助项目(200803114)

摘　　要：目的观察新鲜冰冻血浆在亚甲基蓝光化学法病毒灭活后总蛋白、Ⅷ因子和纤维蛋白原含量变化。方法统计2006年3月至2007年2月随机抽检的48份新鲜冰冻血浆和2007年3月至2008年2月抽检的48份病毒灭活滤白新鲜冰冻血浆,经37℃水浴融化后测定总蛋白、Ⅷ因子及纤维蛋白原含量,进行统计分析。结果新鲜冰冻血浆经过亚甲基蓝光化学法病毒灭活后Ⅷ因子、纤维蛋白原含量明显降低,差异均有统计学意义(P<0.05);总蛋白含量无明显变化(P>0.05)。结论血浆经亚甲基蓝光化学法病毒灭活处理能够提高输血安全性,同时部分血浆成分含量有一定下降。Objective To observe the variation of plasma total protein,concentrate Ⅷ factor and fibrogen after melhylene blue virus inactivation treatment. Methods Using the data of 48 randomly selected fresh frozen plasma and 48 leukocyte-depleted fresh frozen plasma drawn from March 2007 to February 2008 ,we tested and made a retrospective statistics analysis on the changes of total protein,factor Ⅷ and fibrogen after thawed at 37° water bath. Results There was a small decrease in the level of factor Ⅷ and fihrogen. The difference was significant statistically. The level of total protein remains constant. Conclusion MB for plasma virus inactivation leads to significant improvement for blood safety while lower the level of plasma components.

关 键 词：亚甲基蓝 病毒灭活 血浆蛋白 凝血因子 

分 类 号：R457.14[医药卫生—治疗学]