舒芬太尼和芬太尼用于腹腔镜胆囊切除术后患者自控静脉镇痛的比较  

Comparison of patient-controlled intravenous analgesia with sufentanil and fentanil after laparoscopic chlolecystectomy

作　　者：刘东[1] 王超[1] 孙雪梅[1] 徐勇[1] 罗礼君[1] 

机构地区：[1]成都市第二人民医院麻醉科,四川成都610017

出　　处：《四川医学》2010年第7期919-921,共3页Sichuan Medical Journal

摘　　要：目的比较腹腔镜胆囊切除术后应用舒芬太尼或芬太尼进行患者自控静脉镇痛(PCIA)的临床效果和安全性。方法选择60例ASAⅠ～Ⅱ级进行腹腔镜胆囊切除术的患者,随机分为两组,每组30例。舒芬太尼PCIA组药物配方为舒芬太尼100μg+托烷司琼5mg用生理盐水稀释至100ml,负荷量2ml,背景剂量2ml/h,自控给药剂量0.5ml/次,锁定时间15min。芬太尼PCIA组药物配方为芬太尼1mg+托烷司琼5mg用生理盐水稀释至100ml,负荷量2ml,背景剂量2ml/h,自控给药剂量0.5ml/次,锁定时间15min。结果两组术后4、8、12、24、36h各时间点的视觉模拟评分(VAS)差异无统计学意义,两组患者对术后镇痛总体满意度良至优者百分率差异无统计学意义,不良反应发生率舒芬太尼组明显少于芬太尼组。结论舒芬太尼或芬太尼均可安全地用于术后患者自控镇痛,均可取得满意的效果。舒芬太尼不良反应少于芬太尼。Objective To compare the efficacy and safety of patient-controlled intravenous analgesia （PCIA） with sufentanil;and fentanil after laparoscopic chlolecystectomy.Methods Sixty patients,ASA Ⅰ～Ⅱ,undergoing laparoscopic chlolecystectomy operation under anesthesia were randomly allocated to intravenous sufentanil group（n=30）or intravenous fentanil group（n=30）.In sufentanil group,the PCIA solution consisted of sufentanil 100μg,tropane 5mg diluted to 100ml with normal saline,loading dose of 2ml,background infusion 2.0ml/h,bolus 0.5ml,lockout-time 15min;in fentanil group,the PCIA solution consisted of fentanil 1mg,tropane 5mg diluted to 100ml with normal saine,loading dose of 2ml,background infusion 2.0ml/h,bolus 0.5ml,luckout-time 15min.Results At 4,8,12,24 and 36h after operation,there were no significant difference between the two group in VAS scale and the overall satisfaction of pain relief.Concflusion Either intravenous sufentanil or fentanil is satisfied and safe for postoperative pain relief,but sufentanil is with less sideeffects than fentanil.

关 键 词：舒芬太尼 芬太尼 患者自控静脉镇痛 腹腔镜胆囊切除术 

分 类 号：R614[医药卫生—麻醉学]