Electrostatic Interactions Determining the Selectivity of KcsA Channel and Its Mutants  

作　　者：刘玉芝 安海龙 张素花 于慧 展永 张海林 

机构地区：[1]Institute of Biophysics, Hebei University of Technology, Tianjin 300130 [2]Departments of Pharmacology, Hebei Medical University, Shijiazhuang 050017

出　　处：《Chinese Physics Letters》2010年第8期264-266,共3页中国物理快报（英文版）

基　　金：Supported by the National Natural Science Foundation of China under Grant Nos 10775038 and 10975045, the Hebei Provincial Natural Science Foundation under Grant Nos C2009000029 and C2009001104, and Subsidization for Construction Term of Key Subjects in Universities and Colleges of Hebei Province.

摘　　要：We perform the density functional theory and Brownian dynamics simulations based on the three-dimensional structure of the WT KcsA channel and its mutants. Our data suggest that the electrostatic interactions between the channels and cations, within the signature sequence of K^＋ channels, determine the selectivity of the channel.We perform the density functional theory and Brownian dynamics simulations based on the three-dimensional structure of the WT KcsA channel and its mutants. Our data suggest that the electrostatic interactions between the channels and cations, within the signature sequence of K^＋ channels, determine the selectivity of the channel.

分 类 号：O647.2[理学—物理化学] S66[理学—化学]