吲达帕胺及(或)非洛地平对老年高血压患者动态血压的影响  

Effects of indapamide and/or felodipine on ambulatory blood pressure in elderly patients with hypertension

作　　者：付新[1] 黄振文[1] 郭丽[1] 张菲斐[1] 康锐[1] 

机构地区：[1]郑州大学第一附属医院心内科,郑州市450052

出　　处：《中华老年多器官疾病杂志》2010年第2期138-141,共4页Chinese Journal of Multiple Organ Diseases in the Elderly

摘　　要：目的探讨降压药物吲达帕胺缓释片联合非洛地平缓释片在老年高血压患者中的降压效果。方法选择老年高血压病患者150例,平均年龄(65±4)岁,按就诊顺序随机分3组:分别给予吲达帕胺缓释片1.5mg/d、非洛地平缓释片5mg/d和吲达帕胺缓释片1.5mg/d+非洛地平缓释片5mg/d,疗程3个月。观察治疗前后24h、白昼及夜间平均收缩压/舒张压和平均收缩压/舒张压负荷以及平均心率。结果治疗结束时3组24h、白昼和夜间平均收缩压/舒张压均较服药前明显下降;血压负荷值亦明显减少;而联合治疗组与单药治疗组比较下降更明显,差异具有统计学意义。治疗前后心率没有明显变化。结论小剂量长效利尿剂联合钙拮抗剂治疗高血压疗效显著,稳定性好,不良反应少。老年高血压病患者应尽量选择长效利尿剂联合钙拮抗剂。Objective To investigate the efficacy of indapamide/felodipine combination in decreasing blood pressure in elderly patients with hypertension.Methods A total of 150 consecutive elderly cases of hypertension,average age （65.4 ± 3.6） years,were randomized into 3 groups：indapamide group （1.5 mg/d）,felodipine group （5 mg/d）,and indapamide （1.5 mg/d）/felodipine （5 mg/d） combination group,with 50 in each group.The treatment duration was 3 months.The average 24-hour,daytime and night-time systolic blood pressure/diastolic blood pressure and systolic blood pressure/diastolic blood pressure load,as well as mean heart rate,were determined at baseline and after 3 months.Results The average 24-hour,daytime and night-time systolic blood pressure/diastolic blood pressure,and blood pressure load were significantly decreased in all groups after treatment for 3 months,which was more significant in combination group than in single drug treatment group.The mean heart rate showed no significant change after 3 months of treatment.Conclusion Combination of calcium antagonist with long-acting diuretics at low dose provides substantial and stable antihypertensive benefit,and has few side effects.The regimen is strongly recommended for elderly patients with hypertension.

关 键 词：吲达帕胺 非洛地平 老年人 高血压 

分 类 号：R544.1[医药卫生—心血管疾病]