对萼猕猴桃叶中的四个具有细胞毒活性的三萜类成分(英文)  

Four Triterpenoids with Cytotoxic Activity from the Leaves of Actinidia valvata

作　　者：辛海量[1] 吴迎春[2] 徐燕丰[1] 苏永华[1] 张亚妮[1] 凌昌全[1] 

机构地区：[1]第二军医大学长海医院中医系,上海200433 [2]上海中医药大学中药化学教研室,上海201203

出　　处：《中国天然药物》2010年第4期260-263,共4页

基　　金：supported by National Natural Science Foundation of China (No. 30572360);Special Project of TCM Modernization of Science and Technology Commission of Shanghai Municipality (No. 04DZ19808)~~

摘　　要：目的:研究对萼猕猴桃(Actinidia valvata Dunn)叶的的化学成分进行研究。方法:采用多种色谱手段进行分离,通过波谱分析确定化合物结构。选用肿瘤细胞株PLC、Hep3B、HepG2、HeLa、SW480、MCF-7和Bel7402,采用MTT法进行细胞毒活性测试。结果:从对萼猕猴桃中分得4个化合物为科罗索酸(1)、2α,3β,24-三羟基乌苏烷-12-烯-28-酸(2)、2α,3α,24-三羟基乌苏烷-12-烯-28-酸(3)和2α,3α,19α,24-四羟基乌苏烷-12-烯-28-酸(4),它们都具有细胞毒活性。结论:该4个化合物为首次从该实验材料中获得。AIM：To study the chemical constituents of the leaves of Actinidia valvata Dunn.METHODS：Several chromatographic methods were applied to isolate and purify compounds and their structures were elucidated by spectroscopic methods.RESULTS：Four triterpenoids including corosolic acid（1）,2α,3β,24-trihydroxyurs-12-en-28-oic acid（2）,2α,3α,24-trihydroxyurs-12-en-28-oic acid（3） and 2α,3α,19α,24-tetrahydroxyurs-12-en-28-oic acid（4） were isolated from Actinidia valvata Dunn.They all showed in vitro cytotoxic activity against tumor cell lines including PLC,Hep3B,HepG2,HeLa,SW480,MCF-7 and Bel7402.CONCLUSION：These 4 compounds were all obtained from the plant for the first time.

关 键 词：细胞毒 三萜 对萼猕猴桃 

分 类 号：R284.1[医药卫生—中药学]