粘细菌Sorangium cellulosum So0157-2产生的两个埃博霉素类化合物(英文)  

Two Epothilones from Sorangium cellulosum Strain So0157-2

作　　者：赵林[1] 赵宝兵[2] 鲁春华[2] 李越中[1] 沈月毛[1,2] 

机构地区：[1]山东大学粘细菌及医药微生物技术研究室,济南250100 [2]厦门大学生命科学学院福建省药物工程实验室,厦门361005

出　　处：《中国天然药物》2010年第4期298-300,共3页

基　　金：supported by Key Program of International Cooperation, Ministry of Science and Technology of China (No.2007DFA30970);the 863 Program of China (No. 20060102Z1083)~~

摘　　要：目的:对粘细菌Sorangium cellulosum So0157-2的化学成分进行研究。方法:通过色谱层析对提取物进行分离纯化,并通过波谱解析(一维、二维的核磁共振谱和质谱)确定了化合物的结构。结果:分别鉴定为seco-epothiloneA(1)和1-methyl-seco-epothiloneA(2)。结论:化合物1和2都是首次从该菌株中分离得到。其中1是首次分离得到的新天然产物。AIM：To study the chemical constituents of Sorangium cellulosum So0157-2.METHODS：The chemical constituents were isolated and purified by column chromatography,and their structures were identified by spectroscopic analyses including 1D-,2D-NMR data and MS analyses.RESULTS：Two epothilones were purified and identified as seco-epothilone A（1） and 1-methyl-seco-epothilone A（2）.CONCLUSION：1 and 2 were obtained from this strain for the first time,and 1 was a new natural product.

关 键 词：Sorangium cellulosum So0157-2 埃博霉素 NMR 

分 类 号：TQ465[化学工程—制药化工]