LXR激动剂猪脱氧胆酸二甲酰胺对脊椎动物行为的影响  

Effect of LXR agonist hyodeoxycholic acid dimethyl amide on vertebrate behavior

作　　者：王小岩[1] 蔡怀涵[1] 余昊[1] 李小兰[1] 宋青[1] 

机构地区：[1]北京科技大学应用科学学院生物科学与技术系,北京100083

出　　处：《中国医药导报》2010年第21期22-25,共4页China Medical Herald

基　　金：2009年北京市教委共建项目

摘　　要：目的:研究LXR激动剂对脊椎动物中枢神经系统的药理作用。方法:以鱼、鸽子和小鼠三种脊椎动物为实验对象,以LXR激动剂猪脱氧胆酸二甲酰胺为实验药物,设置实验组、空白对照组,观察不同给药剂量对动物行为的影响。结果:本实验发现,在LXR激动剂急性作用于中枢神经系统条件下,实验组动物产生了可观察到的行为变化。结论:本实验初步建立了简单可靠的动物实验方法,为筛选临床上安全有效的LXR受体调节剂建立动物模型。Objective：To study the effect of LXR signaling on vertebrate central nerve system.LXR signaling pathway influences a variety of metabolic networks and homeostasis,especially cholesterol and lipid-related systems.LXR agonists have been suggested in cholesterol management and therapy for cardiovascular diseases.Methods：We conducted a preliminary study using fish,pigeon and mouse,and set experimental group and blank control group to study drug effect of a LXR agonist hyodeoxycholic acid dimethyl amide on vertebrate behavior.Results：The result showed an observable behavior change upon acute agonist dosing.Conclusion：This study establishes simple and reliable animal experiment.Future investigation of LXR signaling on neurological systems is warranted.

关 键 词：LXR 胆固醇 中枢神经系统 脂类代谢 动物行为 

分 类 号：Q95[生物学—动物学]