心肌肌钙蛋白Ⅰ、肌酸激酶同工酶在川崎病急性期心肌损伤诊断中的临床价值  

Clinical assessment of serum cardiac troponin Ⅰ and CK - MB for the detection of myocardial injury in children with kawasaki disease in acute stage.

作　　者：崔泽敏[1] 黄晓利[1] 范徐威[1] Cui Zemin, Huang Xiaoli, Fan Xuwei. （ Nanhai affiliated maternity and children hospital of Guangzhou TCM university, Guangdong 528000 ）

机构地区：[1]广州中医药大学附属南海妇产儿童医院,广东佛山528000

出　　处：《中国保健》2009年第17期681-682,共2页

摘　　要：目的：探讨心肌肌钙蛋白Ⅰ（cTnⅠ）、肌酸激酶同工酶（CK—MB）在川崎病（Kawasaki disease．KD）急性期心肌损伤中的临床诊断价值。方法：检测68例急性期KD患儿和20例正常对照儿童血清cTnⅠ、CK—MB、肌酸激酶（CK）、乳酸脱氢酶（LDH）浓度，并将68例急性期KD患儿分为有合并心脏病变组（A组）33例和无心脏病变组（B组）35例，比较cTnⅠ和CK—MB的敏感性和特异性。结果：KD组与对照组血清CK、LDH浓度无显著差异（P〉0．05），而血清cTnⅠ、CK—MB浓度明显高于对照组（P〈0．01）；在诊断KD急性期心肌损伤cTnⅠ的敏感度（84．85％）和特异度（82．86％）均高于CK—MB的敏感度（66．67％）和特异度（77．14％）。结论：cTnⅠ与CK—MB为诊断KD患儿急性期心肌损伤的特异性指标，但cTnⅠ具有更高的特异性及敏感性。Objective ：To explore the clinical assessment of serum cardiac troponin Ⅰ （ cTn Ⅰ ） and CK - MB for the detection of myocardial injury in children with Kawasaki disease（KD） in acute stage. Methods：Serum levels of cTn Ⅰ ,CK -MB,creatine kinase（CK） ,lactic dehydrogenase （LDH） were determined in 68 children with KD aud 20 controlled children without disease respectively. 68 children with KD were divided into A group with myocardial injury and B group without myocardial injury. Results：There were no significant difference in serum levels of CK, LDH between KD group and the controlled group. The levels of serum cTn Ⅰ and CK - MB in KD group were significant higher than the controlled group. The sensitivity was cTn Ⅰ （84.85%） 〉 CK - MB（66. 67% ） ,and the specificity was cTn Ⅰ （82. 86% ） 〉 CK - MB（77.14% ）. Conclusion：The serum levels of cTn Ⅰ ,CK - MB were specific for diagnosis of myocardial injury in children with KD in acute stage ,and the determination of cTn I is more sencitivity and specificity comparing to CK - MB.

关 键 词：心肌肌钙蛋白Ⅰ 肌酸激酶同工酶 川崎痛 心肌损伤 

分 类 号：R543[医药卫生—心血管疾病;医药卫生—临床医学;医药卫生—内科学]