股骨头成形术治疗兔股骨头无菌性坏死的实验研究  

An Experiment Study on Aseptic Necrosis of the Femoral Head in Rabbits Treated with Femoral Head Plastic Operation

作　　者：刘志国[1] 苏敏罡[1] 李颖[1] 甄玉婷 付兴[1] 

机构地区：[1]河北省保定市第一中心医院,071000

出　　处：《医学研究杂志》2010年第8期68-71,F0003,共5页Journal of Medical Research

摘　　要：目的股骨头成形术对股骨头坏死的预防和治疗的动物实验研究分析。方法 60只中国白兔,随机分为4组,A组为正常组,其余3组在股骨头颈交界处钻孔造成股骨头缺损,并加用95%乙醇30min灌注造成股骨头缺损模型。B组股骨头作为自然修复对照。C组股骨头造成缺损乙醇填充后填充骨水泥。D组股骨头造成股骨头缺损乙醇填充后填充造影剂骨水泥。4组动物于术后12周处死,立即取股骨头标本观察关节软骨性状。然后分别行X线检查及生物力学测试。结果股骨头关节软骨观察及X线摄片均显示骨水泥组和造影剂骨水泥组股骨头外形始终保持完整无变形,4组股骨头高度比值自然修复组比正常组、骨水泥组、造影剂骨水泥组降低,经方差分析有显著性差异(P<0.05)。抗压试验正常组、骨水泥组和造影剂骨水泥组刚度均数均高于自然修复组,有显著性差异(P<0.01)。结论股骨头成形术操作简单、创伤较小,可以保持股骨头外形完整,能暂缓或替代关节置换术,有望成为治疗FicatⅡ～Ⅲ期年轻患者的新型手术方法。Objective To study the femoral head plastic operation for preventing and treating aseptic necrosis of the femoral head. Methods 60 Chinese white rabbits were divided randomly into 4 groups equally. The four groups except A group were made a globose defect and filled with 95% alcohol tampon for 30 minutes . The B group was natural repair group. The rabbits in C group were filled with bone cement after being made defect. The rabbits in D group were filled with bone cement added barium sulfate agent after being made defect. After 12 weeks the four groups were killed . Articular cartilage and X - ray plate were observed and measured immediately. Results The femoral heads of bone cement group and the femoral heads of contrast agent bone cement group kept their outline all the time though the articular cartilage and X -ray plate＇s observation. 12 weeks later, the ratio of the height to the transverse diameter of the femoral head of natural repair group was lower than that of the other three groups, and had significant difference（P 〈 0.05）. The rigidity of natural repair group had significant difference with that of the other three groups, respectively（ P 〈 0.01 ）. Conclusion Femoral head plastic operation was simple and could release pain. And femoral head outline could be kept integrally. It would be a new operation to treat young patients in Ficat Ⅱ-Ⅲ period to postpone or substitute total hip replacement.

关 键 词：股骨头无菌性坏死 股骨头成形术 实验研究 动物模型 治疗 生物力学 

分 类 号：R681.8[医药卫生—骨科学]