低氘水对小鼠免疫调节作用的研究  

Effect of Deuterium Depleted Water on Immunomodulating in Mice

作　　者：连璐[1] 丛峰松[2] 蔡东联[1] 曲丹[1] 林宁[1] 王洁[1] 

机构地区：[1]第二军医大学长海医院临床营养科,上海200433 [2]上海交通大学生命科学技术学院,200240

出　　处：《医学研究杂志》2010年第8期72-75,共4页Journal of Medical Research

摘　　要：目的探讨低氘水(deuterium-depleted water,DDW)对小鼠免疫调节作用的实验研究。方法实验组小鼠以低氘水作为饮用水,对照组饮自来水,饲养6周,分别测定免疫蛋白IgG、IgM的含量,脾脏指数和胸腺指数(mg/g),脾淋巴细胞增生能力,迟发型变态反应,NK细胞活性以及T细胞亚群CD4+和CD4+/CD8+的变化,观察低氘水对小鼠非特异性免疫和特异性免疫功能的影响。结果低氘水能显著提高IgM,脾脏指数的水平和CD4+、CD4+/CD8+的含量。结论低氘水对小鼠非特异性免疫和特异性免疫功能具有一定的增强作用。Objective To evaluate the immunomodulating effects of deuterium - depleted water（DDW） in normal mice. Methods All of the mice were divided into 2 groups： the experimental group which accepted DDW as the water, and the control group. After 6 weeks, IgG, IgM, thymus index, spleen index, the proliferation of spleen lymphocytes, the activity of NK cell,CD4＋ , CD4＋/CD8 ＋ and dinitrofluorobenzeneinduced delayed type hypersensitivity test（DTH） were employed to evaluate the immunomodulating effects of DDW on non -specific and specific immunologic function of normal mice. Results DDW increased the level of IgM, spleen index, CD4＋ and CD4＋/CD8 ＋ . Conclusion DDW improves non - specific and specific immunologic function of normal mice.

关 键 词：低氘水 IGG IGM 迟发型变态反应 NK细胞活性 CD4+ 免疫调节 

分 类 号：R285.5[医药卫生—中药学]