2-羟基-4-(3-甲基-2-丁烯基)氧苯乙酮的合成研究  

Study on Synthesis of (2-Hydroxy-4-(3-methyl-2-butenyloxy)phenyl) ethanone

作　　者：齐小燕[1] 伍林[1] 易德莲[1] 梁爽[2] 王建国[1,3] 黄雯[1] 周锦霞[1] 

机构地区：[1]武汉科技大学应用化学研究所,湖北武汉430081 [2]中南财经政法大学外国语学院,湖北武汉430073 [3]九江学院化学化工学院,江西九江332005

出　　处：《化学与生物工程》2010年第7期34-36,共3页Chemistry & Bioengineering

摘　　要：以2,4-二羟基苯乙酮和异戊烯基溴为原料,合成了药物中间体2-羟基-4-(3-甲基-2-丁烯基)氧苯乙酮。通过TLC得到优化反应条件如下:以丙酮为溶剂、反应温度为65℃、n(2,4-二羟基苯乙酮)∶n(K2CO3)=1∶1.8、n(2,4-二羟基苯乙酮)∶n(异戊烯基溴)=1∶1.8,此时反应时间最短,目标产物收率达73%。Using（2,4-dihydroxyphenyl）ethanone and prenyl bromide as raw materials,（2-hydroxy-4-（3-methyl-2-butenyloxy）phenyl）ethanone was synthesized.The reaction conditions were optimized by thin-layer chromatography（Si gel）.The best conditions were as follows：acetone as solvent,reaction temperature of 65℃,n[（2,4-dihydroxyphenyl）ethanone]∶n（K2CO3）=1∶1.8,n[（2,4-dihydroxyphenyl）ethanone]∶n（prenyl bromide）=1∶1.8.Under above conditions,the yield would reach 73%.

关 键 词：2 4-二羟基苯乙酮 2-羟基-4-(3-甲基-2-丁烯基)氧苯乙酮 合成 

分 类 号：O625.4[理学—有机化学]