毛细管柱气相色谱法测定注射液中丙二醇的含量  

Determination of Content of Propylene Glycol in Injection by Capillary Gas Chromatography

作　　者：付璀莹[1] 孙煌[1] 姜连阁[1] 白政忠[1] 

机构地区：[1]黑龙江省药品检验所,哈尔滨150001

出　　处：《黑龙江医药》2010年第4期495-497,共3页Heilongjiang Medicine journal

摘　　要：目的:建立气相色谱法测定注射液中的丙二醇。方法:采用毛细管柱气相色谱法,FID检测器,色谱柱为HP-INNOWax毛细管柱(30mx0.32mmx0.25μm),载气为氮气,运用程序升温的方法测定注射液中丙二醇的含量。结果:得到线性回归方程为Y=0.000859X+0.009051,相关系数r=0.9992,平均回收率为99.7%(n=9)。结论:方法操作简便、快速,能满足检测注射液中丙二醇含量的要求。Objective：To establish a method for the determination of Propylene glycol in injection.Methods：A high performance gas chromatography method with FID on a HP-INNOWax capillary column.Nitrogen as the carries gas,The intial temperature was kept at 90℃for 0.5min,then raised to 130℃ at a rate of 10℃/min and subsequently sustained for 4min.The calibration curve was linear within the range of 0.06-1.22mg/L.Regression equation：Y=0.000859X＋0.009051,r=0.9992.The recovery we have detected is 99.7%.Results：this method is simple,accurate and convenient.Conclusion：This method was simplicity 、accuracy and can be used for the determination of Propylene glycol in injection.

关 键 词：丙二醇 毛细管柱气相色谱 注射液 

分 类 号：R927.1[医药卫生—药学]