血清载脂蛋白A5水平与冠心病的关系  

The relationship between serum apolipoprotein A5 and coronary heart disease

作　　者：魏红霞[1] 张葵[1] 邱方[1] 倪军[1] 李雷[1] 

机构地区：[1]南京大学医学院附属南京鼓楼医院检验科,南京210008

出　　处：《临床检验杂志》2010年第4期276-278,共3页Chinese Journal of Clinical Laboratory Science

基　　金：南京市科技发展重点项目(ZKM06055)

摘　　要：目的检测血清载脂蛋白A5(apoA5)水平,分析apoA5浓度与血脂、冠心病的关系,探讨其在冠心病发生中的作用。方法收集150例冠心病患者和104例健康体检者血清用自动生化分析仪检测血脂,双抗体夹心ELISA法检测apoA5水平。结果稳定型心绞痛患者血清apoA5浓度为(209.8±52.6)ng/ml,显著低于健康对照组(231.5±57.0)ng/ml,P<0.05。在校正血脂、年龄等因素后,这种关系仍然存在。稳定型心绞痛组女性血清apoA5浓度比男性高[(239.8±53.1)ng/ml vs(194.5±41.7)ng/ml],P<0.05。总人群中,apoA5浓度与年龄(r=-0.24)、TG(r=-0.27)、TC(r=-0.19)、Lp(a)(r=-0.17)呈负相关,与HDL-C呈正相关(r=0.36)。急性冠脉综合征组血清apoA5浓度为(248.6±54.4)ng/ml,显著高于稳定型心绞痛组(209.8±52.6)ng/ml,P<0.01。结论本研究证实apoA5浓度与血TG、Lp(a)和冠心病呈负相关,apoA5是冠心病独立的保护性预测因子。Objective To analyze the relationship between serum apolipoprotein A5（apoA5） and lipid as well as coronary heart disease（CHD）,and to observe the effect of apoA5 on the pathogenesis of CHD.Methods One hundred and fifty CHD patients and 104 healthy controls were enrolled.Serum lipid was detected by a biochemistry analyzer and serum apoA5 was quantitatively measured by a sandwich enzyme-linked immunosorbent assay.Results The concentration of serum apoA5 in stable angina patients was（209.8±52.6） ng/ml,lower than that in healthy controls（231.5± 57.0） ng/ml,P0.05.Even adjusted by serum lipid,age and other factors,the difference was still statistically significant.Serum apoA5 concentration in female stable angina patients were higher than that in male patients [（239.9±53.1） ng/ml vs（194.5±41.7） ng/ml,P0.05].apoA5 was negatively correlated with age,and the concentrations of TG,TC,and lipoprotein（a）（r=-0.24,-0.27,-0.19,-0.17,respectively）,and positively correlated with HDL-C（r=0.36）.Serum apoA5 concentration（248.6±54.4） ng/ml of ACS group was higher than that in stable angina group（209.8±52.6） ng/ml,P0.01.Conclusion The data demonstrate that serum apoA5 concentration was negatively correlated with serum TG,Lp（a）,and CHD.Serum apoA5 concentration may be an independent protective predictor of CHD.

关 键 词：载脂蛋白A5 血脂 冠心病 

分 类 号：R446.1[医药卫生—诊断学]